Feminizing Adrenocortical Carcinoma Without Gynecomastia

July 2017 in “ Oman medical journal ”

Farida Chentli, F. Chabour, Djafer Bouchibane, Nouria Nouar

feminizing adrenocortical carcinoma estrogen adrenal hormones gynecomastia estradiol metastases breast tissue resistance

TLDR A man with a rare adrenal cancer showed unusual symptoms and died four months after diagnosis.

The document described a rare case of feminizing adrenocortical carcinoma in a 44-year-old man who presented with abdominal pain and a large retroperitoneal tumor with numerous metastases. Despite high levels of estrogen and other adrenal hormones, the patient did not exhibit gynecomastia, which is typically a major symptom. The absence of gynecomastia was hypothesized to be due to resistance of breast tissue to estradiol. The patient underwent surgery and chemotherapy but unfortunately died four months after diagnosis. The prognosis for such tumors is generally poor, especially when metastases are present at diagnosis.

View this study on omjournal.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 69 results

community Not sure what else to do, can’t use anti-androgens (Baseline Hormonal Bloodwork included) need advice badly

in Update 6 upvotes 3 years ago

User experienced feminizing side effects from finasteride and tried RU, alfatradiol, and finasteride without success. They are now considering treatments like Stemoxydine, Zix, Minoxidil, Dermarolling, Eucapil, and a hair transplant.

community 2 months of difference with estradiol and spiro (4 months total w/ estradiol & spiro; 4 years of minoxidil and finasteride) (you should not take estradiol or spiro if you look manly and want to continue looking manly)

in Transgender 115 upvotes 1 month ago

Hair regrowth using estradiol, spironolactone, minoxidil, and finasteride, showing significant improvement over four years. HRT is not advised for cis men solely for hair loss due to feminizing effects.

community Anything stronger than DUT out there?

in Finasteride/Dutasteride 14 upvotes 8 months ago

The conversation discusses seeking a stronger treatment than Dutasteride (DUT) for hair loss. Suggestions include combining DUT with RU58841, increasing DUT dosage, and using transgender hormone replacement therapy or testosterone blockers, though some options may have feminizing side effects.

community why isn’t RU / pyri blamed for feminization, whereas spiro is?

in Treatment 1 year ago

User asks if spironolactone can stack with finasteride and pyrilutamide for hair loss treatment. They question why spironolactone is associated with feminizing effects, while RU/pyri/fluridil, which work similarly, are not.

community Hair loss steps, guide to beginners or anyone experiencing hair loss

in Treatment 1 upvotes 1 month ago

The conversation discusses a hair loss treatment regimen involving finasteride, dutasteride, spironolactone, bicalutamide, oral estradiol, microneedling, and minoxidil. The regimen aims to reduce androgenic alopecia by blocking DHT and androgens, with a caution about potential feminizing effects.

community HRT is literal black magic. Fin 1 mg/day @ 4 years, min 2x/day @ 3 years, Estradiol 4mg/day @ 3.5 months, and Spironolactone 100mg/day @ 3.5 months (estra & spiro are medicines you should likely not take if you are a cis man)

in Progress Pictures 118 upvotes 2 months ago

User shared progress on hair regrowth using Fin 1 mg/day for 4 years, Min 2x/day for 3 years, Estradiol 4mg/day, and Spironolactone 100mg/day for 3.5 months. They noted significant hairline recovery and advised against HRT for cis men due to feminizing effects.

Related Research

1 / 1 results

research Feminizing Adrenocortical Carcinoma Without Gynecomastia

2 citations, July 2017 in “Oman medical journal”

A man with a rare adrenal cancer showed unusual symptoms and died four months after diagnosis.