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Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

Chemotherapy often causes temporary hair loss, which is distressing and needs better treatment and support.

Skin fat helps with body temperature control and has other active roles in health.

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.

Nonclassic adrenal hyperplasia is a genetic condition that can cause early puberty and fertility problems, treated with specific steroids.

Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.

The document concludes with guidance for doctors on diagnosing and treating hirsutism effectively and safely.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

Melatonin, usually known for sleep regulation, also has antioxidant properties that can protect skin, stimulate hair growth, and improve skin conditions, with topical application being more effective than oral use.

New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.

Human hair follicles contain a complex network of prostanoid receptors that may influence hair growth.

Menopause-related hormonal changes affect hair but are not the only cause of hair changes in middle-aged women.

Different drugs for prostate-related urinary symptoms work but have various side effects, and treatment should be tailored to the individual.

The document explains hair biology, the causes of hair loss, and reviews various hair loss treatments.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Antiandrogens can help treat skin conditions like acne and excessive hair in women when used carefully.

The Msi2 protein helps keep hair follicle stem cells inactive, controlling hair growth and regeneration.

Using neurohormones to control keratin can lead to new skin disease treatments.

FGF9 controls which receptors it binds to through a process where two FGF9 molecules join, and changes in FGF9 can lead to incorrect receptor activation.

Effective hirsutism management requires identifying the cause, combining new and traditional treatments, and setting realistic expectations for patients.

PGD2 increases androgen receptor activity in hair cells, which could be targeted to treat hair loss.

Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.

The document concludes that non-operative treatment for gender dysphoria is safe and effective, and hormone therapy does not increase cancer risk.

New treatments and early diagnosis methods for permanent hair loss due to scar tissue are important for managing its psychological effects.

Targeted cancer therapies can cause skin side effects, which should be treated early to help patients' quality of life and treatment adherence.