28 citations
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December 2019 in “Skin appendage disorders” This review discusses medication-induced gray hair repigmentation, highlighting that certain anti-inflammatory drugs and melanogenesis stimulators can cause diffuse repigmentation, though evidence remains low-quality and these medications are not currently indicated for this purpose.
1 citations
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June 2023 in “Skin Research and Technology” This study found that two shampoos with different dyeing methods had varying abilities to dye hair and impact hair health, suggesting that individuals should select hair color shampoos based on their personal needs.
January 2004 in “Linchuang pifuke zazhi” This study identified specific genes that are more abundantly expressed in black hair than in gray hair, with black hair displaying higher expression of pigment-related proteins and gray hair showing increased expression of keratin-related genes.
June 2025 in “Clinical Cosmetic and Investigational Dermatology” This study examined the factors contributing to gray hair, such as genetics and lifestyle, and found that while graying correlates with some health conditions, it is primarily a physiological process rather than a pathological one.
This study reported that Soulflower Rosemary Redensyl Hair Growth Serum (Tetragain™) significantly improved hair growth, increased hair thickness, reduced hair fall, and decreased graying over 120 days, with participants rating the treatment as effective and experiencing no adverse effects.
COVID-19 might cause gray hair to regain color.
303 citations
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August 1971 in “The American Journal of Medicine” This report suggests that in vitiligo, melanocytes may be destroyed by the same factors necessary for melanin production, contributing to the skin's depigmentation.
19 citations
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January 2012 in “Annals of Dermatology” This article recommends creating a system to educate users about the ingredients and side effects of hair coloring products and does not report new research findings.
8 citations
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January 2013 in “Annals of Dermatology” This study found that hair dyeing is more common among Korean women than men and among individuals with significant grayness, and it was not linked to higher scalp disease prevalence.
5 citations
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July 2010 in “Journal of life sciences” This study found that gray scalp hair had a higher prevalence of continuous medullation and crenate cuticle type compared to black scalp hair among Bengalee males.
3 citations
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March 2021 in “Cureus” This article reports a rare combination of rapid-onset halo nevi, nonsegmental vitiligo, and premature scalp hair graying.
2 citations
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March 2020 in “Developmental cell” This study reported that stress can induce hair graying in mice through noradrenaline-mediated depletion of melanocyte stem cells in hair follicles, providing a mechanism that connects stress to hair color changes.
1 citations
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June 1942 in “JAMA” This article discusses observations about the relationship between baldness and gray hair in middle-aged men, noting that baldness often precedes grayness, and suggests a possible connection to premature aging, but reports no new data.
April 2026 in “Cosmetics” This study developed and tested a shampoo with semi-permanent dyes designed to gradually cover gray hair, reporting maintained stability and effective gray–black coloration on high-canities hair tresses through eight wash cycles.
April 2026 in “International Journal of Dermatology” 
February 2026 in “American Scientific Research Journal for Engineering, Technology, and Sciences (Global Society of Scientific Research and Researchers)” This study analyzed gray hair, revealing that it differs from pigmented hair in follicular activity, oxidative balance, and structure, impacting coloring processes and necessitating adapted techniques to maintain hair quality.
May 2023 in “Health science reports” This review discusses the harmful effects of coloring shampoos containing trihydroxybenzene on the scalp-skin barrier and emphasizes the need for safer ingredient selection to prevent side effects.
November 2022 in “Skin Appendage Disorders” This study found that a 6-month treatment with 2% palmitoyl tetrapeptide 20 showed no significant improvement in reducing hair graying in patients, despite theoretical potential.
August 2012 in “Fertility and Sterility” Premature gray hair may indicate reduced ovarian reserve but doesn't lower pregnancy chances.
February 2024 in “Genes to Cells” This study observed that tooth loss in mice led to premature graying of hair in the interbrow region, which was possibly due to reduced stimulation of the trigeminal nerve, suggesting that decreased mastication could cause this type of hair graying.
May 2025 in “International Journal Of Science Technology & Management” This study focused on developing a pomade called "Hyung Hair" made from rambutan leaf extract, which showed potential benefits such as reducing hair loss and slowing gray hair growth, with a feasibility analysis indicating the business's viability.
13 citations
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January 2014 in “Postępy Dermatologii i Alergologii” This report describes four cases of patchy, non-scarring alopecia areata that spared gray hairs and affected only pigmented hairs.
2 citations
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January 2023 in “International journal of biological sciences” This review discusses the mechanisms of hair repigmentation and reports no clinical results; the authors suggest further research into topical treatments for reversing gray hair.
September 1941 in “The Science News-Letter” 56 citations
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July 2001 in “International Journal of Clinical Pharmacology and Therapeutics” This article reviews the psychodynamic factors and treatment options for dysmorphophobia, highlighting the need for intensive psychotherapy, and introduces the concept of "Dorian Gray Syndrome.
6 citations
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January 2007 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” This study found that topical application of triiodothyronine (T3) can induce the transition of hair follicles from the telogen to the anagen phase in mice and stimulate hair shaft growth in vitro.
In this case study, a patient experienced darkening of hair color after taking acitretin, an oral retinoid known for potentially causing alopecia, marking a rare and undocumented phenomenon.
7 citations
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July 2020 in “Pigment cell & melanoma research” In this study, RT1640 was found to promote hair pigment system regeneration and expand melanocyte stem cell pools in a mouse model, suggesting potential applications for aging-related hair disorders.
February 1945 in “New England Journal of Medicine” March 1942 in “The Science News-Letter”