Differential Gene Expression Screening Between Black and Gray Hairs Using Subtractive Library and DNA Chip
January 2004
in “
Linchuang pifuke zazhi
”
New to Keratin? There is a guide in the encyclopedia. Read the guide → Studysummary This study identified specific genes that are more abundantly expressed in black hair than in gray hair, with black hair displaying higher expression of pigment-related proteins and gray hair showing increased expression of keratin-related genes.
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The study identified differential gene expression between gray and black hairs using advanced molecular biological tools. In black hairs, genes related to pigment production, such as Pmel17, MART-1, and tyrosinase, were more abundantly expressed. Additionally, the selenium-binding protein (hSBP) gene and the spast gene for spastin protein showed higher expression in black hairs. Conversely, gray hairs exhibited higher expression of genes associated with keratin, trichohyalin, and transmembrane glycoproteins, with ch 17, hRPK.142_H_19 showing particularly high signal intensity.