TLDR PT-20 did not significantly improve gray hair repigmentation.
This study investigated the use of palmitoyl tetrapeptide 20 (PT-20), an α-melanocyte-stimulating hormone analog, for gray hair repigmentation in 14 patients over 6 months. Despite theoretical benefits, the results showed no significant clinical improvement in hair repigmentation, with 78.6% of patients showing no change according to at least two examiners. The study highlights the discrepancy between patient self-assessment and examiner evaluations, possibly due to patient expectations. The authors note the study's limitations, including a small sample size and short duration, and call for further research to validate these findings.
12 citations
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September 2018 in “International Journal of Cosmetic Science” Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.
46 citations
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April 2014 in “PLOS ONE” Gray hair may be caused by lower antioxidant activity in hair cells.
43 citations
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October 2005 in “Molecular and cellular endocrinology” Hair melanocytes help the skin respond to stress and regulate hair pigmentation.
August 2024 in “Applied Sciences” Plant extracts may help prevent or reverse hair graying.
October 2022 in “Southeast Asian journal of health professionals” Hair greying is seen as a sign of aging; temporary fixes like hair dye are used, but a balanced diet and hair care can help manage it.
12 citations
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September 2018 in “International Journal of Cosmetic Science” Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.
New treatments for hair loss should target eight main causes and use specific plant compounds and peptides for better results.
February 2024 in “Skin health and disease” Many popular skincare products claim to prevent aging but lack strong evidence to prove their effectiveness and safety.
