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Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.

Cutaneous gene therapy could become a viable treatment for skin and hair disorders with improved vector development and gene expression control.

Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.

Advancements in nanoformulations for CRISPR-Cas9 genome editing can respond to specific triggers for controlled gene editing, showing promise in treating incurable diseases, but challenges like precision and system design complexity still need to be addressed.

New materials and methods could improve skin healing and reduce scarring.

The AVET system effectively delivers genes to human keratinocytes and may help treat skin diseases.

Nanotechnology shows promise for better hair loss treatments but needs more research for safety and effectiveness.

New pharmaceutical biomaterials, especially nanomaterials, show promise for improving cancer treatment and disease diagnosis.

Self-amplifying RNA could be a better option for protein replacement therapy with lower doses and lasting effects, but delivering it into cells is still challenging.

Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.

Nanomaterials in biomedicine can improve treatments but may have risks like toxicity, needing more safety research.

Applying a special DNA plasmid to the skin can make it thicker and stronger.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Hair restoration has evolved from surgery to drugs to potential gene therapy, with improved results and ongoing research driven by high demand.

Hair follicles could be used for targeted drug delivery, with liposomal systems showing promise for this method.

The gene Foxn1 is important for hair growth, and understanding it may lead to new alopecia treatments.

Hair follicles could be used to deliver drugs effectively, with the right understanding and methods.

Topical treatments can deliver active molecules to skin stem cells, potentially helping treat skin and hair disorders, including skin cancers and hair loss.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Using polyethylenimine-DNA to deliver the hTERT gene can stimulate hair growth and may be useful in treating hair loss, but there could be potential cancer risks.

MC-DNA vector-based gene therapy can temporarily treat CBS deficiency in mice.

Chitosan, a natural substance, can be used to create tiny particles that effectively deliver various types of drugs, but more work is needed to improve stability and control of drug release.

Controlled delivery of specific RNA and IL-4 restored hair growth in mice with autoimmune alopecia.

Scientists turned mouse stem cells into skin cells that can grow into skin layers and structures.

Nanostructured lipid carriers are effective for treating hyperpigmentation in women aged 30-40.

Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.

Modified KGF mRNA helps skin cells grow and move faster, which may improve wound healing.

Surface-modified nanostructured lipid carriers can improve hair growth treatments.