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Hormone therapy is safe and effective for transgender adults, but requires regular monitoring and mental health support.

Hormone therapy and surgeries for transgender individuals affect their skin and hair, requiring specific dermatologic treatments and respectful care.

Testosterone therapy and surgeries like mastectomy improve transgender men's lives and mental health with low risks and high satisfaction.

Genetic counselors should be culturally skilled and aware of transgender patients' unique health risks and needs.

Inclusive and affirming healthcare is essential for improving transgender individuals' quality of life and health.

Transgender patients on hormone therapy experience more acne and hair loss, but less skin inflammation.

Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

The letter suggests testosterone replacement therapy might worsen COVID-19 outcomes.

Female authorship in dermatology publications increased during the COVID-19 pandemic, but women are still underrepresented in senior roles.

Many children and teens referred to gender services receive hormone treatments, but more research is needed on their long-term care and outcomes.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

Gender-affirming dermatology treatments generally improve mental well-being for transgender individuals, but more research is needed.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

The conclusion is that supportive environments are crucial for the mental health and well-being of transgender individuals during gender transition or de-transition.

Estrogen alone can lower testosterone in some transfeminine people.

Estrogen alone may effectively suppress testosterone in some transfeminine individuals.

PrEP for HIV is less effective in transgender women mainly due to low adherence to the treatment.

Some antiandrogens may lower testosterone better than others, but it's unclear which is best for feminization in transgender women; more research is needed.

Transgender females can reach their target estrogen levels using estradiol patches, especially if oral treatments fail or if they're at risk for blood clots. Often, the highest dose patch is needed.

Using 5-alpha-reductase inhibitors, drugs for prostate issues and hair loss, may lead to eye abnormalities in men.

Exogenous testosterone use may be linked to developing hidradenitis suppurativa.

Dihydrotestosterone makes arteries stiffer in female mice by reducing estrogen receptor expression.

Sex hormones' effects on COVID-19 are unclear and more research is needed to understand their potential as treatment.

Men and women respond differently to drugs for COVID-19, high cholesterol, and diabetes, which suggests a need for personalized treatments.

Women may need different blood pressure guidelines than men for heart disease prevention.

Women and men experience different quality of life and symptom distress after kidney transplant with immunosuppressive therapy.

Masculinizing hormone therapy increases the risk of hair loss in transgender and gender-diverse patients.

Testosterone pellets might work for transgender men's hormone therapy, but more research is needed.

Surgeons must understand the full care process for gender confirmation surgery to help transgender individuals effectively.