Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study demonstrated that elevated GABA levels can worsen stress-induced hair growth inhibition in mice, while GABAA antagonists like ginkgolide A may help alleviate these effects.

This study demonstrated that sodium valproate accelerates skin healing and reduces necrosis in a rat model of skin flap potentially through mechanisms involving GABA and histone deacetylase pathways.

This study reported that in rat retinas under high pressure, allopregnanolone synthesis increased and helped reduce pressure-induced damage through GABAA receptors, suggesting potential therapeutic use in glaucoma.

This study found that diazepam had an exaggerated effect on GABA-related inhibitory tone in diabetic neuropathic mice compared to normal mice, potentially due to mitochondrial dysfunction affecting neurosteroid synthesis.

This study found that blocking GABA(A) receptors in cat dorsal horn neurons increased evoked activity and background discharge, highlighting differences in inhibitory control systems compared to glycine receptors.

The researchers found that inhibiting soluble epoxide hydrolase, either genetically or pharmacologically, delayed the onset of chemically induced seizures related to GABA antagonism in experimental models.

This study found that the antidepressant-like effect of fluoxetine in mice was only observed when a 5-minute pretest session was conducted, and this effect was blocked by the TSPO antagonist PK11195.

This study found that inhaling toluene reduces core temperature in mice, with GABA receptors and neurosteroids involved at 4000 ppm, but different mechanisms contributing at 6000 ppm.

This study found that progesterone can inhibit spinal reflex potentiation in ovariectomized rats through GABA(A) receptor activity, mediated by neurosteroid metabolism rather than direct progesterone receptor action.

This study found that stimulation with certain neurotransmitters and hormones suggests the involvement of 5α-reduced neurosteroids in glial cell differentiation in rat C6 glioma cells.

This study reported that progesterone reduces cell death in hippocampal cultures following oxygen–glucose deprivation mainly through its conversion to allopregnanolone and the involvement of GABAA receptors.

This study found that Asiasari radix extract may reduce hyperalgesia in mice by modulating NMDA and GABAA receptor activities without affecting cyclooxygenase activity.

This study suggests that the anticonvulsant effects of deoxycorticosterone in young rats may be mediated by its metabolites and interactions with multiple receptors, including mineralocorticoid and progesterone receptors.

This study found that progesterone protects rat Purkinje cells during oxygen-glucose deprivation by activating GABA A receptors through its metabolite, allopregnanolone.

This study found that in a rat model, 14,15-EET may alleviate central poststroke pain by enhancing thalamic inhibition through neurosteroid signaling, potentially outperforming gabapentin in early-stage treatment.

This study found that the antiseizure activity of midazolam primarily occurs through synaptic GABA-A receptors, with no significant involvement of endogenous neurosteroids or extrasynaptic receptors.

This study found that progesterone reduces neuronal injury from tributyltin exposure in rat hippocampal slices through a mechanism dependent on allopregnanolone and GABAA receptors.

This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.

This study concluded that 16β-methyl-17α-benzoyloxypregnen-4-en-3,20-dione may be a promising treatment for androgen-dependent diseases and epilepsy due to its antioxidant effects and impact on GABAergic and serotonergic metabolism in rats.

In this study, socially defeated mice showed increased alcohol consumption, and CRF-R1 antagonism selectively reduced drinking in these mice, suggesting a potential treatment target for stress-related alcohol use disorders.

This study suggests that neurosteroids and compounds acting on GABA(A) receptors, like THIP, may modulate ethanol intake by influencing drinking patterns.

This study found that progesterone pretreatment in rats potentiated the effect of ethanol on mesocortical dopamine levels, suggesting an influence of neuroactive steroids on ethanol's action.

This study observed that acute stress in rats increased neurosteroid levels linked to enhanced GABA(A) receptor function, raising seizure thresholds, while similar effects were seen in mice with deoxycorticosterone administration.

This study found that neurosteroids can reorganize GABA A receptors in mice, mimicking ovarian cycle changes, with the process being mediated by neurosteroid levels rather than direct hormone receptor activation.

This study found that finasteride increased fetal arousal activity in late gestation sheep by suppressing pregnane steroid synthesis, suggesting reduced GABAA receptor-mediated inhibition.

This study found that in rodent models, the ability of D1 dopamine receptor activation to impair sensory gating is facilitated by 5α-reductase type 1, which produces allopregnanolone.

This study found that inhibiting neurosteroidogenesis affected GABA A receptor-mediated synaptic inhibition in immature rats but not in adults, suggesting age-dependent modulation of synaptic strength in the spinal dorsal horn.

This review proposes focusing on relationships between neuroactive steroids and psychiatric disorder symptoms, rather than relying on traditional disorder classifications, and reports no new clinical findings.

This review discusses how neurosteroids acting on GABAA receptors may influence behavior and explores the potential for developing selective modulators for treating psychiatric disorders, but reports no new clinical results.

Neurosteroids may help metyrapone reduce cocaine addiction.