81 citations
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November 2012 in “Journal of the National Cancer Institute” This study found that FLCN deficiency in mice muscles led to increased mitochondrial biogenesis and a metabolic shift towards oxidative phosphorylation, with a similar advantage observed in FLCN-null kidney cancer cells.
1 citations
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July 2023 in “Cureus” This report describes a rare case of pili multigemini, where multiple hair shafts arise from a single follicle, discovered during an examination for folliculitis on a patient's abdomen.
October 2023 in “Indian dermatology online journal” This report describes a case study of a 23-year-old female exhibiting multiple trichodiscomas, a type of benign tumor of the hair follicular discs common in familial cases and potentially linked to Birt-Hogg-Dube syndrome, though genetic testing was not performed due to financial constraints.
34 citations
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June 2020 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, researchers observed that follicular damage and stem cell loss in frontal fibrosing alopecia may be mediated by immune attacks at the bulge region, suggesting potential for JAK/STAT-targeting treatments to prevent progression.
January 2017 in “프로그램북(구 초록집)” This report describes a case of acquired trichorrhexis nodosa in a woman with severe iron deficiency anemia, highlighting a possible link between the two conditions.
May 2024 in “JCI insight” In this study, researchers discovered a dominant variant in the ADAM17 gene that causes hypotrichosis with woolly hair, where the mutation leads to hair follicle stem cell exhaustion and abnormal hair follicles, resulting in alopecia.
This article describes a new hair transplant technique combining FUT and FUE to increase graft numbers in patients with high levels of baldness and reduced scalp laxity, but it does not report clinical outcomes.
This study describes a system called FOLLYSIS©, which uses mathematics and image analysis to optimize Follicular Unit Extraction hair transplants, showing high accuracy in measuring donor area density and reducing donor site injury.
50 citations
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September 2012 in “Developmental Biology” This study found that over-expressing Spry4 and Fgf10 modulates feather stem cells to alter feather morphologies in distinct ways, affecting barb branch formation and tissue structure.
11 citations
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September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a distinct CD49fhigh mesenchymal stem cell subpopulation in the dermis that supports hair follicle development and maintenance via Notch signaling activation.
1 citations
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August 2024 in “Anais Brasileiros de Dermatologia” This review discusses the non-follicular skin manifestations of frontal fibrosing alopecia and how they affect diagnosis and treatment, but reports no new clinical results.
June 2021 in “International journal of research in dermatology” This case report describes a man with trichorrhexis nodosa of the beard, who experienced symptomatic improvement after being advised to shave and avoid brushing, confirming the diagnosis.
4 citations
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November 2006 in “Dermatologic Surgery” This study found that the survival of transplanted transected hair follicles is related to the level of transection, but their growth at the recipient site is not satisfactory, leading to a recommendation against transplanting sectioned parts.
1 citations
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September 2023 in “International Journal of Dermatology” In this study conducted at a tertiary dermatological clinic, researchers identified and described the clinical, dermoscopic, and histopathological features of preclinical folliculitis keloidalis, including novel dermoscopic findings such as perifollicular scale, which was associated with fibrosis.
June 2022 in “Research Square (Research Square)” This study revealed that nestin-expressing progenitor cells capable of becoming ORS keratinocytes are present during both hair follicle development and in adult hair follicles.
This study reports that patients with specific MFN2 mutations, including p.Arg707Trp, exhibit significant upper body fat overgrowth with suppressed leptin production, suggesting tissue-selective mitochondrial dysfunction and potential therapeutic targets.
January 2000 in “The Mouseion at the JAXlibrary (Jackson Laboratory)” This study identified a new mouse mutation associated with noninflammatory proliferative skin disease and hair abnormalities, drawing parallels to human conditions like Netherton's syndrome and monilethrix.
47 citations
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August 2016 in “American Journal Of Pathology” This study reports that in systemic sclerosis, CD34+ dermal fibroblasts transition to CD34−, podoplanin+, and CD90+ fibroblasts across the dermis, suggesting a role in unchecked fibrosis.
45 citations
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August 1992 in “PubMed” In this study, researchers found that changes in the extracellular matrix components, particularly fibronectin, laminin, and type IV collagen, during the rat vibrissa follicle growth cycle, suggest dynamic remodeling related to dermal-epidermal signaling.
40 citations
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January 2013 in “International journal of trichology” This study found that among women with frontal fibrosing alopecia, 100% showed dermoscopic elements suggestive of the condition, with perifollicular erythema often indicating disease activity.
February 2025 in “Veterinary Clinical Pathology” In this study, a ferret with multiple health issues was diagnosed with a malignant apocrine gland adenocarcinoma on the prepuce, highlighting the aggressive nature of such tumors in this species and suggesting further investigation into cytologic features could provide insights into tumor behavior.
September 2023 in “Journal of the American Academy of Dermatology” This study examined the application of new clinical guidelines for diagnosing frontal fibrosing alopecia in 18 men, highlighting that current diagnostic criteria may often overlook early beard involvement and sideburn recession.
November 2023 in “Indian Journal of Dermatology” This study from North-East India analyzed 21 cases of frontal fibrosing alopecia, noting a high prevalence in post-menopausal women and distinct histological features such as perifollicular lymphocytic infiltrate and hydropic degeneration.
38 citations
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September 2014 in “Cell and Tissue Research” This review explores the infundibulum's role and importance in skin diseases and emphasizes the need for further research into its biology and potential therapeutic targeting, but it presents no new findings.
28 citations
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June 1995 in “The Journal of Dermatology” This study reports that flaky skin mice exhibit skin and nail features that closely resemble human psoriasis vulgaris, suggesting they may serve as a natural model for this condition.
February 2011 in “Journal of the American Academy of Dermatology” This study found that polycystic ovary syndrome was the most common cause of hirsutism among premenopausal women in Algeria.
1 citations
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September 2021 in “CRC Press eBooks” This chapter reviews trichoscopic-pathologic correlations in Frontal Fibrosing Alopecia and reports no new clinical results; the authors discuss genetics, clinical patterns, and unusual variants associated with this condition.
July 2025 in “Journal of Medical Science And clinical Research” In this case report, a 21-year-old male was observed to have primary essential cutis verticis gyrata, a condition characterized by the excessive formation of scalp folds resembling cerebral gyri, without any additional comorbidities.
November 2023 in “International surgery journal” In this case study, a 69-year-old male with a neck swelling was diagnosed with a trichilemmal cyst, highlighting the importance of complete surgical excision for lesions with proliferative or malignant potential.
May 2025 in “Oral Sciences Reports” This case study reports that a 45-year-old woman developed a painless nodule in the lower lip four weeks after receiving hyaluronic acid filler, which required surgical removal, highlighting the potential for delayed complications from lip augmentation procedures.