13 citations
,
February 2021 in “Brain Sciences” This study found that in adolescent male rats, androgens enhance inhibitory avoidance memory, possibly by interacting with androgen receptors in the amygdala and hippocampus.
13 citations
,
September 2020 in “Sensors” This study used melamine formaldehyde particles to measure a pH gradient along the hair shaft, showing a significant pH decrease from the hair sheath to the external shaft.
13 citations
,
August 2020 in “Asian Journal of Pharmaceutical Sciences” This review outlines the mechanisms, applications, and development prospects of label-free imaging technologies in transdermal research and reports no new clinical results.
13 citations
,
May 2017 in “Current Protocols in Stem Cell Biology” This study outlines a method to isolate hair follicle stem cells from mouse skin using fluorescence activated cell-sorting for use in research models, but reports no experimental findings.
13 citations
,
April 2016 in “Journal of Visualized Experiments” This study describes a method for isolating stem cells and keratinocytes from mouse hair follicles using FACS technology, facilitating the study of stem cell biology.
13 citations
,
December 2010 in “Nature Reviews Endocrinology” A young man with an eating disorder had a life-threatening adrenal crisis due to an autoimmune condition, highlighting the need for better education on managing hormone treatments.
13 citations
,
July 2009 in “Pediatrics in Review” This review discusses the diagnosis and treatment of 21-hydroxylase deficiency in congenital adrenal hyperplasia and emphasizes the need for earlier detection and proper management; it reports no clinical results.
12 citations
,
March 2012 in “ATLA. Alternatives to laboratory animals” This study found that caffeine and flufenamic acid penetrated porcine skin more effectively through hair follicles, while the importance of the follicular pathway varied for other substances tested.
11 citations
,
August 2000 in “Journal of Endocrinology” In this study, treatment with DHEA induced mild to moderate hyperplasia of sebaceous glands in ovariectomized rats, which was prevented by the antiandrogen Flutamide but not by the antiestrogen EM-800.
11 citations
,
June 2016 in “European Journal of Medicinal Chemistry” This study found that two synthesized androst-4-ene-3-one derivatives, 6f and 6g, exhibited stronger anti-proliferative effects than common drugs on prostate cancer cell lines, with low toxicity to rat cells.
11 citations
,
May 2016 in “PubMed” This article reviews various methods and introduces new imaging technologies to assess the effects of hair shaping treatments on hair chemistry and structural integrity, without reporting clinical results.
11 citations
,
January 2016 in “International Journal of Biological Macromolecules” This study found that enzymatic phosphorylation of hair keratin increased its capacity to adsorb cationic components like methylene blue and may have practical implications for hair care products.
11 citations
,
September 2015 in “Theriogenology” Testosterone boosts fluid and electrolyte secretion in seminal vesicles, aiding sperm function.
11 citations
,
August 2009 in “Dermatologic Surgery” A man developed a rare scalp disorder, Folliculitis Decalvans, 20 years after hair restoration surgery, and it required long-term antibiotic treatment.
11 citations
,
May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology” This review explores the evaluation and treatment of hirsutism, emphasizing a systematic approach to uncovering its causes and recommending combination therapies for effective management, but presents no new results.
10 citations
,
December 2019 in “in Vivo” This study found that administering testosterone to ovariectomized female rats decreased endometrial tight junction complexity and expression of specific proteins, potentially affecting embryo implantation.
10 citations
,
May 1995 in “Journal of General Internal Medicine” Most women with excessive hair growth have PCOS; treatment varies and focuses on preventing new hair, with electrolysis as the only permanent removal method.
10 citations
,
June 2019 in “International Journal of Pharmaceutics” Hair removal methods damage the skin barrier and affect substance penetration.
10 citations
,
January 2014 in “Chemical and Pharmaceutical Bulletin” This study found that hair follicle-plugging reduced skin permeation of certain model drugs, with effects varying based on EtOH pretreatment and the drug being evaluated.
10 citations
,
January 2011 in “Skin research and technology” This study found that procyanidin oligomers bind to keratin and inhibit oxidative hair damage, suggesting their potential use in protective hair care products.
10 citations
,
January 2010 in “Indian journal of dermatology, venereology, and leprology” This study found that long pulsed Nd: YAG laser is a safe and effective method for hair reduction in individuals with skin types IV and V, with significant improvements observed over six sessions.
9 citations
,
March 1991 in “Endocrinology” This study in rats suggests that combining the 5 alpha-reductase inhibitor 4-MA with the antiandrogen Flutamide may enhance prostate cancer therapy by additively inhibiting prostatic growth and mRNA levels of androgen-sensitive prostatic binding proteins.
9 citations
,
June 2020 in “Actas Dermo-Sifiliográficas” This source suggests that spironolactone, a potassium-sparing diuretic, is underutilized in dermatology despite evidence showing its potential benefits for female acne, hidradenitis suppurativa, and female androgenetic alopecia, noting its long-term safety and reduced need for additional testing in young women.
9 citations
,
January 2017 in “Archives of biochemistry and biophysics” In this study, testosterone was reported to increase aquaporin levels and water reabsorption in the kidneys of male rats, potentially leading to higher blood pressure, with effects mitigated by flutamide and finasteride.
9 citations
,
January 2016 in “Journal of cosmetology & trichology” This article reviews the characteristics and distribution of alopecia areata and reports no new clinical results.
9 citations
,
April 2015 in “Dermatologic Therapy” This review discusses the use of hormonal therapies for managing acne vulgaris in adult women and reports no new clinical results, emphasizing the chronic and severe nature of acne in this population.
9 citations
,
October 2012 in “Frontiers of Hormone Research” This review discusses the causes and treatments of hirsutism, emphasizing identifying potentially life-threatening pathologies, but it reports no new clinical results.
9 citations
,
November 2004 in “Bioorganic & Medicinal Chemistry Letters” This study identified potent dual inhibitors of 5α-reductases 1 and 2 that may aid in designing new drugs for related diseases.
9 citations
,
September 2002 in “The Journal of clinical investigation/The journal of clinical investigation” This study found that reducing testosterone levels in male mice accelerates wound healing and decreases inflammation, suggesting a potential therapeutic target for improving wound repair in elderly males.
9 citations
,
April 1999 in “Mammalian Genome” This study reports that the acidic and basic keratin gene clusters in dogs are located on chromosomes CFA9 and CFA27, respectively, similar to genetic arrangements in humans and mice.