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The 2023 guideline advises a detailed approach for PCOS, focusing on early detection, lifestyle and medical treatments, and managing health risks.

Hormone treatment for transgender patients may not need to be stopped before surgery, but more research is needed, especially on estrogen.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

PCOS causes infertility mainly due to hormonal imbalances, insulin resistance, and chronic inflammation.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Laser treatment can effectively reduce unwanted hair growth, particularly for people with fair skin and dark hair.

The review suggests a comprehensive approach to treat hirsutism, focusing on hair removal, medication, and managing emotional effects.

Finasteride effectively reduces hair growth in women with polycystic ovary syndrome or idiopathic hirsutism.

Lifestyle changes and clomiphene are first-line treatments for infertility in women with PCOS, with other options available if these fail.

Polycystic Ovary Syndrome is linked to higher risk of hypertension and heart disease.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.

Using anabolic androgenic steroids can cause serious, lasting health problems in many parts of the body.

PCOS in teen girls should be managed with lifestyle changes and sometimes medication to improve symptoms and health.

Diagnosing PCOS is challenging due to its complex and varied symptoms.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

Second-generation antipsychotics offer no significant benefit over first-generation ones for schizophrenia.

Baricitinib shows promise as a new treatment for certain skin conditions like alopecia areata.

Hair loss can indicate various health issues, including serious diseases, hormonal imbalances, and can significantly affect personal life and mental health.

Most dermatologic medications are safe during pregnancy and breastfeeding, but some should be avoided due to potential risks.

Platelet-Rich Fibrin (PRF) can speed up healing in chronic wounds, improve hair density, and act as a natural filler for skin rejuvenation, but its use in hair loss treatment needs more evaluation.

A 37-year-old male with severe skin and internal issues has a rare inherited skin condition called dystrophic epidermolysis bullosa.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Many patients on new leukemia drugs had mild to moderate skin reactions.

The document concludes that regenerating functional ectodermal organs like teeth and hair is promising for future therapies.

The new hair transplant device reduces damage to hair follicles and makes surgery more comfortable for the surgeon.

Baricitinib is a promising treatment for severe alopecia areata with minimal side effects.

Gene therapy helped rats with a specific type of rickets grow hair without severe inflammation.