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      Gender Differences in Skin: A Review of the Literature

      research Gender differences in skin: A review of the literature

      152 citations , December 2007 in “Gender Medicine”
      This review discusses recent advances in understanding gender differences in skin and their implications for dermatologic diseases, but it reports no new experimental results; ongoing research is necessary for translating these insights into clinical practice.
      Androgenetic Alopecia: An Evidence-Based Treatment Update

      research Androgenetic Alopecia: An Evidence-Based Treatment Update

      151 citations , May 2014 in “American Journal of Clinical Dermatology”
      This review concluded that oral finasteride for men and topical minoxidil for both genders have the most evidence supporting their effectiveness and safety for treating androgenetic alopecia.

      research Localization of sex steroid receptors in human skin.

      147 citations , April 2004 in “PubMed”
      This study identifies specific localization patterns of androgen, estrogen, and progesterone receptors in human skin, which could be crucial for understanding their roles in skin biology and pathology.
      Hormone Therapy for Transgender Patients

      research Hormone therapy for transgender patients

      146 citations , December 2016 in “Translational Andrology and Urology”
      This review discusses the creation of transgender-specific guidelines by WPATH and the Endocrine Society, based mostly on clinical experience, and reports no new results.
      Hormone Replacement Therapy and the Skin

      research Hormone replacement therapy and the skin

      138 citations , May 2000 in “Maturitas”
      This review discusses the effects of estrogen on skin and reports no new clinical results; it highlights estrogen's potential benefits on skin thickness, collagen quality, and hair follicle life cycle.
      Intracrine Androgen Biosynthesis, Metabolism, and Action Revisited

      research Intracrine androgen biosynthesis, metabolism and action revisited

      131 citations , September 2017 in “Molecular and Cellular Endocrinology”
      This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.
      Clinical Management of Youth with Gender Dysphoria in Vancouver

      research Clinical Management of Youth with Gender Dysphoria in Vancouver

      116 citations , December 2013 in “The Journal of Pediatrics”
      This study reported that treatment with gonadotropin-releasing hormone analogs and cross-sex hormones appears appropriate for carefully selected youth with gender dysphoria, but long-term safety needs further investigation.
      Melatonin and the Hair Follicle

      research Melatonin and the hair follicle

      109 citations , October 2007 in “Journal of pineal research”
      This study suggests that melatonin plays a role in hair follicle function by modulating growth and pigmentation, and it may act as a protective agent in active hair growth phases.

      research Management of Transgenderism

      108 citations , February 2013 in “JAMA”
      This review discusses the therapeutic options for transgender individuals, including hormonal and surgical treatments, and reports no new clinical results; the authors highlight the need for more research on long-term effects.

      research Steroid sulfatase inhibitors

      108 citations , April 2004 in “Medicinal Research Reviews”
      This review discusses the medicinal chemistry of steroid sulfatase inhibitors for estrogen- and androgen-dependent disorders but reports no new clinical results.

      research Hormonal Effects on Hair Follicles

      102 citations , July 2020 in “International journal of molecular sciences”
      This review discusses the effects of hormonal changes on hair follicles, concluding that hormones like androgens and estradiol significantly influence hair growth and cycle, while the roles of other hormones are still being researched.
      Endocrine Aspects of Female Sexual Dysfunction

      research Endocrine Aspects of Female Sexual Dysfunction

      100 citations , July 2004 in “The Journal of Sexual Medicine”
      This article reviews how various hormones may affect female sexual function and provides recommendations for diagnosing and treating endocrinologic sexual difficulties, but it reports no new clinical results.
      Endocrine Control of Benign Prostatic Hyperplasia

      research Endocrine control of benign prostatic hyperplasia

      97 citations , April 2016 in “Andrology”
      This review discusses the etio-pathogenetic factors in benign prostatic hyperplasia and their role in the development of lower urinary tract symptoms but reports no new research findings.
      Intracrinology and the Skin

      research Intracrinology and The Skin

      82 citations , January 2000 in “Hormone Research in Paediatrics”
      This study describes the enzymatic processes through which DHEA is converted to active sex steroids in human skin, highlighting an androgenic effect on sebaceous glands and estrogenic effects in the vagina.
      Pharmacologic Interventions in Aging Hair

      research Pharmacologic interventions in aging hair

      80 citations , April 2006 in “Clinical Interventions in Aging”
      This review discusses factors affecting hair aging and the current pharmacological treatments for androgenetic alopecia, mentioning topical minoxidil and oral finasteride, but does not present new clinical findings.
      Current Evaluation of Amenorrhea

      research Current evaluation of amenorrhea

      78 citations , November 2008 in “Fertility and Sterility”
      Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.
      Skin Connective Tissue and Aging

      research Skin connective tissue and ageing

      77 citations , July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”
      This review discusses the impact of menopause-related oestrogen deficiency on skin ageing and suggests that oestrogen use may improve collagen and skin elasticity, but it reports no clinical trial results.
      Acne and Systemic Disease

      research Acne and Systemic Disease

      76 citations , November 2009 in “Medical Clinics of North America”
      This article reviews the hormonal and medication-related factors associated with acne development but does not present new research findings.

      research Sex hormones and acne

      76 citations , October 2016 in “Clinics in dermatology”
      This review discusses the hormonal and genetic factors influencing acne development, emphasizing the role of androgens and insulin signaling but reports no new clinical results.
      Skin Aging

      research Skin ageing

      76 citations , May 2007 in “Menopause International”
      This review discusses the relationship between estrogen deficiency and skin aging in postmenopausal women, noting potential benefits of estrogen use on skin collagen and elasticity, but reports no new clinical results.

      research The skin as an endocrine organ

      75 citations , September 2009 in “Dermato-endocrinology”
      This review discusses the skin's role in producing hormones and related substances, highlighting their potential in homeostasis and disease management, and reports no new clinical findings.
      Estrogen Functions in Skin and Skin Appendages

      research Oestrogen functions in skin and skin appendages

      68 citations , June 2005 in “Expert Opinion on Therapeutic Targets”
      This review discusses the influence of oestrogens on various skin components and highlights their modulatory roles and receptor pathways, but it reports no new clinical results.
      The Role of Nuclear Hormone Receptors in Cutaneous Wound Repair

      research The role of nuclear hormone receptors in cutaneous wound repair

      68 citations , December 2014 in “Cell Biochemistry and Function”
      This review examines the role of nuclear hormone receptors in skin wound repair processes and reports no new clinical results, highlighting the importance of their interaction with skin cells for effective healing.