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This research review observed that topical hormone replacement therapy, particularly estradiol and estradiol-testosterone combinations, significantly increased Type I and III collagen synthesis in the skin of postmenopausal women, suggesting benefits against collagen loss-related skin aging effects such as reduced elasticity and increased dryness.

Most transgender patients getting laser hair removal before gender-affirming surgery are already on hormone therapy, which might affect the hair removal process.

This study concluded that current cross-sex hormone treatments for trans men and trans women are effective with a low risk of side effects in the short term, though they did observe specific clinical changes.

This review summarizes the use of chlormadinone acetate for hormone replacement therapy and contraception, highlighting its anti-androgenic effects, contraceptive efficacy, and clinical tolerability, without offering new clinical results.

This review highlights therapeutic options for inducing puberty in males and females with delayed puberty, emphasizing the need for larger trials to establish the best approaches.

This study reports that transdermal exposure to owners' topical hormone replacement therapy caused alopecia in six dogs, but the condition resolved after the therapy was discontinued.

This study observed that cyclosporine A significantly alters sex hormone levels in both pre- and post-menopausal women with primary biliary cirrhosis.

This study reports experience treating 140 women with hirsutism and other virilism signs using cyproterone acetate and ethinyl estradiol, focusing on those treated for over five months.

This systematic review reported that gender-affirming hormone therapy may lead to changes in hair growth patterns, with differing effects for transgender men and women, potentially impacting quality of life.

This review discusses the roles of glucocorticoid and sex hormone receptors in the skin and their clinical importance, but reports no new research findings.

The research examined Crown-X, a novel formulation containing Menstrual Stem Cells, and found that it promoted significant proliferation of human dermal papilla cells, suggesting its potential as a non-invasive treatment for male pattern baldness. Future clinical trials are necessary to confirm its efficacy.

This case study observed that in four middle-aged men with ejaculation disorders, therapy with human chorionic gonadotropin (hCG) alone or combined with recombinant follicle-stimulating hormone (rFSH) improved sexual desire, semen volume, and various other symptoms, although some experienced elevated estradiol levels and hair loss.

This review found moderate to very low-quality evidence that spironolactone, flutamide, and cyproterone acetate combined with oral contraceptives may reduce hirsutism more effectively than placebo or metformin, though results vary among other treatments.

This systematic review concluded that 5 mg of oral finasteride per day could be an effective and safe treatment for female pattern hair loss in normoandrogenic women, particularly when combined with other medications.

This review discusses the causes and management of hirsutism, recommending low-dose oral contraceptives with flutamide over cyproterone-containing preparations, but reports no new clinical findings.

This study found that cyproterone acetate, given with ethinyl oestradiol, significantly reduced hirsutism in women after 12 months, although improvements reversed once cyproterone acetate was stopped.

This study found that spironolactone reduced androgenic hormones in hirsute women but had only marginal effects on hair growth, making it no more advisable than other therapies.

This study found that proxalutamide improved immunologic, inflammatory, thrombotic, and oxygen markers in both female and male COVID-19 outpatients, which may support its association with lower hospitalization rates compared to standard care.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

This case report describes a 46,XY female patient with a novel homozygous nonsense mutation in the LHCGR gene, highlighting the need for molecular analysis in disorders of sexual development.

This review discusses developments in oral contraceptives, highlighting improved individualization, reduced side effects, and enhanced suitability for various women's health needs, but it reports no new clinical results.

This review discusses the diagnosis, management, and hormone treatment of transsexual individuals, and examines the risks and effects of cross-sex hormone therapy without presenting new clinical results.

This review discusses hormone replacement therapy for women with premature ovarian insufficiency, strongly recommending it for symptom relief and bone protection, but notes a lack of evidence on optimal types and doses.

In this case report, a transgender woman experienced scalp hair regrowth after approximately six months of oral estradiol and spironolactone treatment, achieving testosterone levels within the normal female range.

This review discusses medical interventions that reproductive health experts can provide to transgender and gender diverse youth and reports no new clinical results.

This case report describes a young female with a rare combination of 46,XX gonadal dysgenesis and MRKH syndrome, highlighting associated infertility challenges.

This case study found that in a male-to-female transgender individual, long-term cyproterone use led to decreased bone mass, which improved with additional oestradiol treatment, highlighting the anabolic role of oestrogens on bone health.

This review discusses the changes in androgen levels with age in women and the potential benefits of testosterone replacement therapy as part of hormone replacement therapy for postmenopausal women, but it reports no new clinical results.

Transgender patients with hair loss need personalized treatment plans considering their unique needs.

This case report describes a 10-year multidisciplinary treatment of a transgender woman in Slovenia, reporting a successful medical and social transition with stable emotional health, abstinence from alcohol, and no regrets following her transition.