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Flutamide caused damage to male rat reproductive organs and may affect fertility.

Finasteride treatment for three years changes certain polyamine levels in the blood but not in urine.

Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.

Combination of 0.25% finasteride and 3% minoxidil works better than just 3% minoxidil for increasing hair thickness in women.

Finasteride harms Daphnia magna's reproduction and metabolism.

Higher early lead exposure is linked to delayed puberty in girls.

Removing Sprouty genes in mice causes various hormone-related issues but does not increase cancer risk by one year of age.

PFOS exposure disrupts hormone levels and enzyme activities in juvenile frogs, affecting males and females differently.

The article concludes that correctly diagnosing systemic causes of hair loss requires a detailed clinical evaluation and a systematic diagnostic approach.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

High androgen levels can cause excessive hair growth and may indicate serious health issues, including heart disease and fertility problems.

Smoking and alcohol worsen hair transplant results.

Coloring shampoos for gray hair may cause gene mutation, reproductive issues, and skin damage, needing stricter regulation and expert consultation.

Certain diets may help with hair growth in people with different types of hair loss.

Women with hair thinning have disrupted steroid hormone levels, but this doesn't often show as other health issues. More research is needed on hormone balance in this condition.

Acute illnesses like sepsis can disrupt thyroid hormone balance without central hypothyroidism.

Alopecia areata is caused by immune system attacks on hair follicles, often triggered by viral infections.

Secondary amenorrhea has many causes and requires thorough evaluation to treat and restore menstrual cycles.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

Lower SHBG levels may increase the risk of PCOS.

Hormone imbalances from the pituitary, thyroid, and adrenal glands can cause infertility, but treating these disorders can improve fertility.

Hormonal therapies are safe and effective for treating acne in female adolescents, with specific treatments for those with endocrine disorders.

Irregular menstrual cycles in exercising women may be linked to energy deficiency or hormonal imbalances, requiring careful diagnosis for proper treatment.

PCOS affects many women and requires early detection and symptom management.

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

Many women experience sexual dysfunction, but few seek help, and better treatment and medical training are needed.

The document concludes that more multidisciplinary research is needed to understand and treat PCOS, a condition that significantly affects women's health and quality of life.

Accurate diagnosis and tailored treatments are crucial for managing hair loss in humans and animals.

Different types of PCOS need specific diagnosis methods and treatments.

Chemotherapy caused a woman's permanent hair loss and early menopause.