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The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.

St. John's Wort extract and oil safety in cosmetics is unclear; more data needed on photosensitization, toxicity, and human irritation.

Curcumin can be effectively loaded into polystyrene nanoparticles, which are safe for human cells and more biocompatible with curcumin inside.

Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.

Some psychoactive drugs can cause skin reactions, with carbamazepine having a higher risk, and stopping the drug and seeing a dermatologist is important.

A machine learning model called CATNIP can predict new uses for existing drugs, like using antidepressants for Parkinson's disease and a thyroid cancer drug for diabetes.

Some skin medications can have harmful interactions with the COVID-19 drug nirmatrelvir-ritonavir, but not with molnupiravir.

Nanoparticle-based drug delivery to hair follicles is more effective when tested under conditions that match skin behavior.

New skin disease treatments using TDDS are improving but face challenges like side effects and high costs.

Nanofiber scaffolds help wounds heal by delivering drugs directly to the injury site.

The drug Albendazole, used for treating parasites, can cause sudden hair loss.

Chitosan-decorated nanoparticles can improve skin delivery and reduce side effects of finasteride.

Methotrexate caused a rare skin rash in a rheumatoid arthritis patient, which resolved after stopping the drug.

Certain cancer drugs interact with skin bacteria to cause acne-like rashes.

Phenytoin, a medication, can cause hair loss and trigger a condition similar to lupus.

Biodegradable polymers can improve cannabinoid delivery but need more clinical trials.

Drug repositioning offers hope for new, affordable treatments for a genetic skin disorder called ARCI.

Using existing drugs for new purposes could be a cost-effective way to treat chest pain and non-clogged heart arteries, with some drugs for lung blood pressure showing promise but needing more testing.

Understanding drug interactions, side effects, and patient-specific factors is crucial for effective dermatological care.

Proper skin toxicity management in chemotherapy is key to continuing treatment and keeping patient quality of life high.

A cancer drug caused unusual hair growth on a 100-year-old man's scalp and eyelashes.

Nanotechnology is improving drug delivery and targeting, with promising applications in cancer treatment, gene therapy, and cosmetics, but challenges remain in ensuring precise delivery and safety.

The document concludes that doctors should carefully consider off-label drug use in dermatology and always inform patients, while more research is needed on the safety and effectiveness of such practices.

Using three different drugs together may better treat eye diseases like glaucoma and macular degeneration.

Microneedles are a promising method for drug delivery, offering efficient and convenient alternatives with fewer side effects.

Nanostructured delivery systems could potentially improve hair loss treatment by targeting drugs to hair follicles, reducing side effects and dosage, but the best size, charge, and materials for these systems need further investigation.

Skin reactions are a common reason for emergency visits due to drug allergies, with some severe cases needing intensive care.

Pemetrexed with cisplatin is safer and more effective than gemcitabine with cisplatin for advanced lung cancer.