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    Glossary Drug Repositioning

    finding new uses for existing medications

    Drug Repositioning, also known as Drug Repurposing, is the process of finding new therapeutic uses for existing medications. This approach can save time and resources in drug development because the safety profiles of these drugs are already well understood, allowing for quicker transitions to clinical trials for new indications.

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    1. Drug Repositioning: New Approaches and Future Prospects for Life-Debilitating Diseases and the COVID-19 Pandemic Outbreak Viruses · 2020 · 170 citations
    2. Drug repositioning: current approaches and their implications in the precision medicine era Expert review of precision medicine and drug development · 2018 · 42 citations
    3. Network-Based Drug Repositioning: Approaches, Resources, and Research Directions Methods in molecular biology · 2018 · 39 citations
    4. Drug Repositioning with GraphSAGE and Clustering Constraints Based on Drug and Disease Networks Frontiers in Pharmacology · 2022 · 32 citations
    5. Drug repositioning using <i>in silico</i> compound profiling Future Medicinal Chemistry · 2009 · 24 citations
    6. Knowledge Mapping of Drug Repositioning’s Theme and Development Drug Design Development and Therapy · 2023 · 5 citations
    7. Drug Repositioning: New Opportunities for Older Drugs Elsevier eBooks · 2019 · 4 citations
    8. Peer Review #3 of "Computational drug repositioning based on side-effects mined from social media (v0.1)" 2016
    9. Drug repositioning approach to target ‎viral and host cells in terms of COVID-19 treatment: A review of ‎in vivo experiments and clinical studies Journal of experimental and clinical medicine · 2022
    10. Repositioning Old Drugs for New Battles: The Expanding Role of Drug Repurposing in Cancer, Inflammation, and Metabolic Disease. BIOMED natural and applied science · 2025 · 3 citations
    11. Recent advances in drug repositioning and rediscovery for different therapeutic activities utilizing updated technological approaches Molecular Diversity · 2025 · 4 citations
    12. Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches PROTEOMICS · 2025
    13. Improving the treatment of bacterial infections caused by multidrug-resistant bacteria through drug repositioning Frontiers in Pharmacology · 2024 · 15 citations
    14. Review of Drug Repositioning in Cancer Therapeutics Asian Journal of Research in Chemistry · 2024
    15. A review on computer‐aided chemogenomics and drug repositioning for rationalCOVID‐19 drug discovery Chemical Biology & Drug Design · 2022 · 48 citations
    16. Sexual dimorphism of COVID-19 inspires drug repositioning and host-targeting immunotherapy for viral pneumonia Signal Transduction and Targeted Therapy · 2026
    17. Peer Review #3 of "Computational drug repositioning based on side-effects mined from social media (v0.3)" 2016
    18. Peer Review #2 of "Computational drug repositioning based on side-effects mined from social media (v0.1)" 2016
    19. Peer Review #2 of "Computational drug repositioning based on side-effects mined from social media (v0.2)" 2016
    20. Peer Review #1 of "Computational drug repositioning based on side-effects mined from social media (v0.1)" 2016
    21. Peer Review #3 of "Computational drug repositioning based on side-effects mined from social media (v0.2)" 2016
    22. Identification of neprilysin as a potential target of arteannuin using computational drug repositioning Brazilian Journal of Pharmaceutical Sciences · 2017
    23. Computational Drug Discovery in Chemotherapy-induced Alopecia via Text Mining and Biomedical Databases Clinical Therapeutics · 2019 · 3 citations
    24. Advances in the treatment of autosomal recessive congenital ichthyosis, a look towards the repositioning of drugs Frontiers in pharmacology · 2023
    25. BH17 Bridging the gap: identifying dual-targeting therapies for patients with alopecia areata and coexisting immune-mediated inflammatory diseases British Journal of Dermatology · 2025
    26. Prospects of integrated multi-omics-driven biomarkers for efficient hair loss therapy from systems biology perspective Gene Reports · 2022
    27. Drug Repurposing in Dermatology: Molecular Biology and Omics Approach IntechOpen eBooks · 2020 · 1 citations
    28. DrugNet: Network-based drug–disease prioritization by integrating heterogeneous data Artificial Intelligence in Medicine · 2015 · 158 citations
    29. LINCS Dataset-Based Repositioning of Dutasteride as an Anti-Neuroinflammation Agent Brain Sciences · 2021 · 6 citations
    30. High-content drug screening for rare diseases Journal of Inherited Metabolic Disease · 2017 · 29 citations