research Role of Drug Repurposing in Sustainable Drug Discovery
Drug repurposing speeds up drug development, saves money, and has led to about a third of new drug approvals.
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research Drug News
The FDA approved a new breast cancer treatment, found flu shots may reduce heart risks, questioned the safety of fast-tracked drug approvals, showed statins don't help with certain pneumonia, and approved a new dementia imaging agent.
research Industry Update: The Latest Developments in the Field of Therapeutic Delivery, July 2018
New partnerships, clinical trials, and drug approvals marked progress in therapeutic delivery in July 2018.
research Drug Repurposing: Hypothesis, Molecular Aspects, and Therapeutic Applications
Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.
research Why Do Promising Therapies Stall in Development and How Can We Move Them Forward?
Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.
research LabeledIn: Cataloging Labeled Indications for Human Drugs
Researchers created LabeledIn, a detailed list of drug uses, showing the importance of human input in making such lists.
research Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One
Adding a second method to PROTACs could improve cancer treatment.
research Pharma in the Bedroom and the Kitchen: The Pharmaceuticalisation of Daily Life
The conclusion is that the increasing use of drugs for lifestyle reasons is a complex issue influenced by corporate profit, consumer behavior, and the medicalization of everyday life, with potential negative effects on personal well-being.
research A Primer on Cosmetics for Dermatologists
Dermatologists need to know about cosmetics to help patients with skin issues and recommend safe products.
research Comparative Efficacy and Safety of JAK Inhibitors in the Treatment of Moderate-to-Severe Alopecia Areata: A Systematic Review and Network Meta-Analysis
Brepocitinib 30mg is most effective for moderate-to-severe alopecia areata, but ritlecitinib 50mg may offer a better balance of safety and effectiveness.
research Safety and Efficacy of a Topical Treatment (SM04554) for Androgenetic Alopecia: Results from a Phase 1 Trial
Dutasteride more effective than finasteride for hair growth; SM04554 safe and potentially effective for hair loss.
research Randomized Controlled Evaluator Blinded Study of Dutasteride Versus Finasteride in Men With Androgenetic Alopecia
Dutasteride more effective than finasteride for hair growth; SM04554 safe and potentially effective for hair loss.
research Withdrawn
Dutasteride works better than finasteride for hair growth with similar side effects.
research Relapsing Nail Fibrokeratoma: A Case Report on a Teenager
Dutasteride is more effective than finasteride for hair growth with similar side effects.
research Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy
Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.
research Personalized Medicine in the Field of Inflammatory Skin Disorders
Personalized medicine is important for treating skin disorders, with new treatments and connections to hormones and genetics being explored.
research The Role of Entrepreneurial Leadership and Innovation in the Future of Therapeutic Dermatology
Entrepreneurial companies are key to advancing dermatology treatments and patient care.
research The Chinese State Food and Drug Administration Has Issued Sinovac Biotech a New Drug Certificate Approving Its Split Influenza Vaccine
China approved Sinovac's flu vaccine, Japan approved RiUP for female hair loss, and Nippon Kayaku's three cancer drugs.
research A Comparative Study of Regulations of Cell and Gene Therapy in the US, EU, and India
The US and EU lead in cell and gene therapy regulations with more approvals and clinical trials, while India is in early stages with fewer approvals and expedited processes.
research Controversies in Off-Label Prescriptions in Dermatology: The Perspective of the Patient, the Physician, and the Pharmaceutical Companies
The document concludes that doctors should carefully consider off-label drug use in dermatology and always inform patients, while more research is needed on the safety and effectiveness of such practices.
research Shedding Light on the FDA’s 510(k) Approvals Process: Low-Level Laser Therapy Devices Used in the Treatment of Androgenetic Alopecia
LLLT devices for hair loss need more research to define proper guidelines.
research What's New in Androgenetic Alopecia: Approvals, Long-Term Safety Data, Cancer Risk and Treatment Options for Women
research Medication Clusters at Hospital Discharge and Risk of Adverse Drug Events at 30-Days Post-Discharge: A Population-Based Cohort Study of Older Adults
Certain groups of medications given when leaving the hospital are linked to a higher risk of negative drug reactions within 30 days, especially in older adults with respiratory issues.
research Off-Label Prescription and Challenges in Clinical Practice: An Abridged Review
The review suggests doctors should carefully weigh risks and benefits of off-label drug use, involve patients in decisions, and calls for better regulations and monitoring.
research Industry Updates from the Field of Stem Cell Research and Regenerative Medicine in June 2019
In June 2019, the stem cell research field saw major progress, including new clinical trials, FDA approvals, and industry collaborations.
research Phospholipid-Polymer Hybrid Nanoparticle-Mediated Transfollicular Delivery of Quercetin: Prospective Implementation for the Treatment of Androgenic Alopecia
Quercetin-loaded nanoparticles can penetrate skin, minimize hair loss, and promote hair regrowth, showing slightly better results than a marketed product.
research The Role of Therapy in Impairing Quality of Life in Dermatological Patients: A Multinational Study
Skin treatment can lower life quality for patients with skin conditions.
research Reporting on Adverse Clinical Events
Some medications and supplements can cause serious side effects, including hair loss, heart rhythm problems, liver injury, and other health issues.
research Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing
The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.
research The History of the Development of Minoxidil
Minoxidil was first made for high blood pressure, but it was later found to help hair growth.