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GlossaryDoxorubicin

chemotherapy drug that interferes with cancer cell DNA

Doxorubicin, also known as Adriamycin, is a chemotherapy drug used to treat various types of cancer, including breast cancer, bladder cancer, and lymphoma. It works by interfering with the DNA inside cancer cells, preventing them from growing and dividing. However, it can also cause side effects such as hair loss (alopecia) and damage to the heart, so its use is carefully monitored by healthcare professionals.

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Reduced Cardiotoxicity and Comparable Efficacy in a Phase III Trial of Pegylated Liposomal Doxorubicin HCl (CAELYX/Doxil) Versus Conventional Doxorubicin for First-Line Treatment of Metastatic Breast Cancer

research Reduced Cardiotoxicity and Comparable Efficacy in a Phase III Trial of Pegylated Liposomal Doxorubicin HCl (CAELYX/Doxil) Versus Conventional Doxorubicin for First-Line Treatment of Metastatic Breast Cancer

1461 citations, March 2004 in “Annals of oncology”

Pegylated liposomal doxorubicin is as effective as conventional doxorubicin but causes fewer heart problems and side effects.

research Pegylated Liposomal Doxorubicin: Metamorphosis of an Old Drug into a New Form of Chemotherapy

522 citations, January 2001 in “Cancer investigation”

Doxil is an effective, modified chemotherapy drug with a unique toxicity profile and shows promise in treating certain cancers.

research Pegylated Liposomal Doxorubicin in the Treatment of Breast Cancer

108 citations, December 2003 in “Clinical breast cancer”

PLD is an effective and safer alternative for treating breast cancer.

research Prevention of Doxorubicin-Induced Alopecia by Scalp Hypothermia: Relation to Degree of Cooling

53 citations, June 1982 in “The BMJ”

Cooling the scalp below 22°C before and during chemotherapy can help prevent hair loss.

research Minoxidil as a Prophylaxis of Doxorubicin-Induced Alopecia

49 citations, October 1994 in “Annals of Oncology”

Minoxidil not effective in preventing chemotherapy-induced hair loss.

research The Circular RNA circNlgn Mediates Doxorubicin-Induced Cardiac Remodeling and Fibrosis

19 citations, June 2022 in “Molecular therapy. Nucleic acids”

A specific RNA, circNlgn, contributes to heart damage and scarring caused by the cancer drug doxorubicin.

A Medicinal and Edible Formula YH0618 Ameliorates the Toxicity Induced by Doxorubicin via Regulating the Expression of Bax/Bcl-2 and FOXO4

research A Medicinal and Edible Formula YH0618 Ameliorates the Toxicity Induced by Doxorubicin via Regulating the Expression of Bax/Bcl-2 and FOXO4

17 citations, January 2019 in “Journal of cancer”

The formula YH0618 can reduce the harmful side effects of the chemotherapy drug Doxorubicin and protect healthy cells.

research Doxorubicin-Induced Hair Loss in the Angora Rabbit: A Study of Treatments to Protect Against Hair Loss

12 citations, December 1987 in “Cancer Chemotherapy and Pharmacology”

Vitamin E in the diet might help protect against hair loss caused by the chemotherapy drug doxorubicin in rabbits.

research Chemoprevention of Doxorubicin-Induced Alopecia in Mice by Dietary Administration of L-Cystine and Vitamin B6

11 citations, June 2012 in “Archives of Dermatological Research”

L-cystine and vitamin B6 at high doses prevented hair loss in mice treated with a chemotherapy drug.

Chinese Herbal Medicine, Guilu Erxian Glue, as Alternative Medicine for Adverse Side Effects of Chemotherapy in Doxorubicin-Treated Cell and Mouse Models

research Chinese Herbal Medicine, Guilu Erxian Glue, as Alternative Medicine for Adverse Side Effects of Chemotherapy in Doxorubicin-Treated Cell and Mouse Models

9 citations, April 2021 in “Evidence-based complementary and alternative medicine”

Guilu Erxian Glue may help reduce chemotherapy side effects like weight loss and heart stress.

iTRAQ-Based Quantitative Proteomics Revealing the Therapeutic Mechanism of a Medicinal and Edible Formula YH0618 in Reducing Doxorubicin-Induced Alopecia by Targeting Keratins and TGF-β/Smad3 Pathway

research iTRAQ-Based Quantitative Proteomics Revealing the Therapeutic Mechanism of a Medicinal and Edible Formula YH0618 in Reducing Doxorubicin-Induced Alopecia by Targeting Keratins and TGF-β/Smad3 Pathway

June 2024 in “Heliyon”

YH0618 helps reduce chemotherapy-induced hair loss by targeting specific proteins and pathways.

research Cepharanthine Inhibits Doxorubicin-Induced Cellular Senescence by Activating Autophagy via the MTOR Signaling Pathway

January 2023 in “Discovery medicine”

Cepharanthine helps reduce cell aging caused by the cancer drug Doxorubicin by boosting cell cleanup processes.

research TRAIL Sensitization of PC3 Prostate Cancer Cells by Doxorubicin Can Be Blocked by the Antioxidant N-Acetyl-Cysteine or by the Iron Chelator Deferoxamine

October 2006 in “Clinical Cancer Research”

Antioxidants can block the cancer-fighting effects of doxorubicin.

research Pathogenesis of Hand-Foot Syndrome Induced by PEG-Modified Liposomal Doxorubicin

63 citations, February 2013 in “Human cell”

PEGL-DOX causes Hand-Foot Syndrome due to skin reactions from prolonged circulation and ROS generation.

research Cytoprotective Effects of Natural Honey Against Doxorubicin Toxicity in Mice

5 citations, January 2014 in “Advances in bioscience and biotechnology”

Natural honey protects against Doxorubicin's harmful effects.

research A Local Drug Delivery System Based on Visible Light-Cured Glycol Chitosan and Doxorubicin Hydrochloride for Thyroid Cancer Treatment In Vitro and In Vivo

27 citations, January 2018 in “Drug Delivery”

GC10/DOX hydrogel shows promise as an effective thyroid cancer treatment.

research Copper-Doxorubicin as a Nanoparticle Cargo Retains Efficacy with Minimal Toxicity

102 citations, October 2010 in “Molecular Pharmaceutics”

Copper-doxorubicin nanoparticles effectively treat tumors with less toxicity.

research Development of PEGylated Liposomes

October 2011

PEGylated liposomal doxorubicin improves cancer treatment effectiveness and reduces side effects like heart damage and hair loss.

research Anthracycline Analogs: The Past, Present, And Future

168 citations, December 1986 in “Cancer Chemotherapy and Pharmacology”

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

research Synergistic Effect of Soursop Leaf Extract (Annona Muricata Linn) and Doxorubicin on MCF-7 Breast Cancer Cells

October 2024 in “Media Farmasi”

Combining soursop leaf extract with doxorubicin may improve breast cancer treatment and reduce side effects.

Postoperative Chemotherapy and Tamoxifen Compared with Tamoxifen Alone in the Treatment of Positive-Node Breast Cancer Patients Aged 50 Years and Older with Tumors Responsive to Tamoxifen: Results from the National Surgical Adjuvant Breast and Bowel Project B-16

research Postoperative Chemotherapy and Tamoxifen Compared with Tamoxifen Alone in the Treatment of Positive-Node Breast Cancer Patients Aged 50 Years and Older with Tumors Responsive to Tamoxifen: Results from the National Surgical Adjuvant Breast and Bowel Project B-16

279 citations, June 1990 in “Journal of Clinical Oncology”

Adding chemotherapy to tamoxifen improves survival for older breast cancer patients with positive nodes.

research Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

153 citations, January 2001 in “Science”

Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.

$Doxil (Caelyx): An Exploratory Study with Pharmacokinetics in Patients with Hormone-Refractory Prostate Cancer$

research Doxil (Caelyx): An Exploratory Study with Pharmacokinetics in Patients with Hormone-Refractory Prostate Cancer

81 citations, February 2000 in “Anti-cancer drugs”

Doxil showed some effectiveness against advanced prostate cancer but caused severe side effects at higher doses.

research Mitoxantrone

60 citations, June 1997 in “Drugs & Aging”

Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.

research Cutaneous Reactions to Chemotherapeutic Agents

53 citations, May 2001 in “The American journal of the medical sciences”

Chemotherapy can cause various skin problems, and recognizing them helps improve patient care.

research Scalp Cooling Has No Place in the Prevention of Alopecia in Adjuvant Chemotherapy for Breast Cancer

39 citations, January 1994 in “European Journal of Cancer”

Scalp cooling is largely ineffective in preventing hair loss from breast cancer chemotherapy.

research Hair Growth In Vitro From Histocultured Skin

25 citations, August 1992 in “In vitro cellular & developmental biology”

The new system can grow hair in the lab and test hair growth treatments.

Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy

research Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy

12 citations, July 2014 in “Journal of Investigative Dermatology”

Chemotherapy causes complex changes in hair follicle cells that can lead to hair loss.

research Alopecia and Hair Damage Induced by Oncological Therapy

7 citations, October 2019 in “Klinická onkologie”

Cancer treatments often cause hair loss and damage, affecting patients' mental health.

research Lifestyle and Adiponectin Level: Four-Year Follow-Up of Controlled Trials

5 citations, July 2010 in “Archives of Internal Medicine”

Prostaglandins may protect hair follicles during chemotherapy.