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This review discusses the role of Edar signaling in hair follicle development and cycling, emphasizing its impact on cell fate, differentiation, and interactions with other pathways, but reports no new results.

This review discusses recent discoveries about the role of Eda and other TNF-related cytokines in skin appendage development and reports no new experimental results, highlighting developments since the last comprehensive summary in 2003.

This study found that while Eda and Edar proteins interact in vitro, their roles in dental development differ, with downless mutant mice showing distinct tooth defects compared to tabby mutants.

This study explains how the development of keratin-associated proteins in embryonic epidermis is crucial for forming protective barriers in vertebrates, enabling them to adapt to terrestrial environments.

This study found that transplanted ES cell-derived epidermal stem cells promoted the formation of epidermis, sweat gland-like, sebaceous gland-like, and hair follicle-like structures in mouse skin defects.

In this study, researchers discussed how specific protein interactions in reptile skin allow for the development of protective structures like scales and scutes, which facilitated reptiles' adaptation to terrestrial environments.

This study found that nerve-mediated HDAC1 expression is necessary for blastema formation and limb regeneration in axolotls, and that inhibiting HDACs delays or inhibits this process.

A 4kb fragment of the desmocollin 3 promoter targets gene expression to specific skin and hair follicle areas.

The researchers reported that in hairless mice, epidermal cell division orientations and epidermal thickness varied by body site, with dorsal and ear epidermis primarily dividing parallel to the basement membrane, unlike hind paw and tail epidermis.

This study concluded that label-retaining cells in mouse epidermis differ in their sensitivity to proliferative stimuli, influencing their division and potential transdifferentiation without consistently depleting their population.

This study identifies two previously unreported pathogenic RIPK4 gene variants, suggesting a functional link with cell adhesion molecules in ectodermal dysplasias.

This study observed that dermal dendritic cells migrate to the epidermis in mouse tail and back skin, correlating with changes in epidermal physiology like ortho- and parakeratosis.

This study found that Prdm1 is crucial for whisker development in mice, affecting multiple signaling pathways and possibly playing a role in primates' evolutionary loss of vibrissae.

This study found that Cutl1 mutant mice experienced retarded lung differentiation and abnormal hair follicle morphogenesis, indicating the vital role of CDP in lung development and hair follicle cell-lineage specification.

This case report describes a novel NECTIN4 gene mutation linked to ED-syndactyly syndrome 1 in a young girl, contributing to the understanding of this rare ectodermal dysplasia.

The authors concluded that the dermal response to epidermal Wnt/β-catenin signaling depends on distinct fibroblast lineages, with each responding to different paracrine signals such as Hedgehog and TGF-β.

This study suggests that human embryonic stem cells may improve skin graft quality and functionality by enabling the identification and amplification of early ectodermal progenitors, pending confirmation from preclinical studies.

In this study, researchers explored the molecular and cellular traits of avian reticulate scales, finding that they lack localized stem cell niches for regeneration, unlike other scale types, leading to repair but not regeneration after wounding.

This study found that enteroendocrine cells play a key role in coordinating stem cell migration towards wounds in the Drosophila intestinal epithelium, aiding tissue repair through non-canonical Wnt signaling.

This study found that Cathepsin E plays a crucial role in keratinocyte terminal differentiation, affecting epidermis formation and homeostasis in mice.

In this study, EDA-A2 transgenic mice exhibited multifocal myodegeneration dependent on XEDAR, suggesting a potential role for XEDAR in skeletal muscle homeostasis.

In this mouse study, researchers found that the absence of laminin-511 in skin delays hair follicle development and disrupts hair shaft differentiation, affecting key transcription factors for hair keratins.

This study reports that corneal transient amplifying cells can be reprogrammed into epidermal cells capable of forming hair follicles in response to embryonic dermis signals.

This study found that zebrafish and stickleback fish use similar genetic programs for tooth regeneration, despite differences in their dental structures.

Adult hair follicle cells can create new hair follicles from corneal cells with the right support.

This study describes the otolaryngologic manifestations and multidisciplinary management strategies for 12 patients with ectodermal dysplasia, emphasizing the importance of early recognition for effective treatment.

This study found that the Foxn1(-/-) nude phenotype significantly influences epithelial progeny in skin, with notable changes in stem cell niches not achievable in other models.

In this study, researchers used advanced techniques to map the early embryonic development of mouse skin, identifying diverse cell populations and uncovering complex interactions essential for skin structure, signaling, and function.