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Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Androgens can both increase and decrease hair growth in different parts of the body.

Scientists found new nonsteroidal compounds that can act like natural male hormones and might help treat male fertility and hormone issues.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

High levels of 3 alpha-diol glucuronide in the blood are a marker of increased androgen action in women with excessive hair growth of unknown cause.

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

DHT in the human prostate is produced through multiple pathways, not just from testosterone.

Prostate cancer was a major health issue in 2009, especially for Black men, and targeting the 5alpha-reductase enzyme could help in its prevention and treatment.

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.

Spironolactone reduced hair thickness and some testosterone levels in women with excessive hair growth.

Finasteride effectively blocks enzyme causing male pattern baldness.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Finasteride effectively treats baldness but may cause sexual side effects.

Testosterone's muscle-building effects do not require its conversion to DHT.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

Higher androgen levels and site-specific AR expression cause sex-related skeletal differences, and certain steroids can boost AR expression and androgen effects in bone cells.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

Insufficient androgen action in male fetuses can cause genital development issues due to genetic mutations or environmental chemicals.

Testosterone treatment in trans men increases body and facial hair and may lead to hair loss over time, but severe skin issues are rare.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Hormones like testosterone and estrogen significantly affect hair growth and structure.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Male accessory sex glands in rats rarely develop tumors and respond to hormones.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

New compounds called benzoquinolinones may treat conditions linked to excess DHT.