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DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

Testosterone affects stress hormone levels differently in adolescent and adult male rats.

Sex hormones affect brain cells differently in males and females.

Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.

The document explains how male reproductive hormones work and affect the body.

Anti-androgen drugs can treat conditions like prostate cancer and male pattern baldness by blocking effects of testosterone and DHT.

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.

Topical finasteride may help treat facial hirsutism in women.

Isotretinoin and tazarotene help treat acne, while minoxidil and finasteride promote hair growth.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

Antiandrogens can treat female hormonal conditions, but environmental ones may harm reproductive health.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Combining light therapy with certain substances improves hair growth in people with hair loss.

Aromatase inhibitors cause male pattern hair loss in women.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

A 13-year-old with 46 XY DSD had ambiguous genitalia due to incomplete masculinization.

Y27632 increases cell growth through EGFR signaling, not ROCK1/2.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

Male hormones worsen kidney transplant damage, but blocking them helps.

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

Dihydrotestosterone causes p27 protein breakdown in ovarian and breast cancer cells by binding with SKP2.

Scientists made all eight versions of a compound called cyoctol, but found it's not an anti-androgen and it fully breaks down in the skin.

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

Compound 15a was effective in inhibiting 5α-reductase.

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.