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30-60 / 1000+ resultsresearch Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor
This study found that dutasteride more effectively reduced serum dihydrotestosterone levels than finasteride in patients with benign prostatic hyperplasia.
research A REVIEW ON COLOURFUL MEHENDI: THE RISK OF PARAPHENYLENEDIAMINE
This article highlights the health risks associated with adding paraphenylenediamine to mehndi, such as contact dermatitis and asthma, and emphasizes the need for regulatory checks as its use grows among cancer patients, women with alopecia, and pregnant individuals.
research Utilization of Wilalondahi (Archidendron lucyi) as an Antihemorrhagic and Wound Healing Alternative Based on Ethnomedicine
This study found that a 15% concentration of Wilalondahi bark extract gel significantly improved wound healing and reduced inflammation in mice, with wounds completely healed by day 9, demonstrating comparable effectiveness to the positive control.
research Kaempferol Rhamnosides from Geranium sibiricum as Aldose Reductase Inhibitors and Their Content by HPLC Analysis
This study suggests that G. sibiricum has potent aldose reductase inhibitory activity, primarily due to kaempferol rhamnosides, and may be further explored as a natural treatment for diabetes-related complications.
research Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells
This study found that arctiin, a compound from Arctium lappa, demonstrated protective effects against oxidative stress-induced dysfunction in human hair dermal papilla cells, suggesting potential therapeutic use for alopecia.
research ARTS, an unusual septin, regulates tumorigenesis by promoting apoptosis
This review examines the molecular mechanisms by which the proapoptotic protein ARTS inhibits tumorigenesis and discusses prospects for developing drugs that mimic its function, with no new experimental results reported.
research Effect of Trigonella foenum-graecum Linn. (seeds) and Butea monosperma Lam. (flowers) on chemotherapy- induced alopecia Trigonella foenum-graecum Linn. (tohum) ve Butea monosperma Lam. (çiçek)'in kemoterapi ile uyarilan alopesi üzerine etkileri
This study found that a polyherbal formulation of Trigonella foenum-graecum seeds and Butea monosperma flowers significantly promoted hair growth and reduced dihydrotestosterone levels in a chemotherapy-induced alopecia model.
research EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF AMALGAMATION OF KUTKUTI (TRIDAX PROCUMBENS) AND GINGER JUICE AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN RATS.
This study reported that the combination of tridax procumbens and ginger juice improved antioxidant activity and protected against liver damage induced by paracetamol in rats, suggesting a potent hepatoprotective effect.
research LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure
This study found that extracts from Geranium pyrenaicum show promising antioxidant, enzyme inhibitory, and antiviral activities, particularly the methanolic extract's antiviral activity against HSV-1.
research Formulasi dan Evaluasi Aktivitas Antijamur Gel Sampo Anti ketombe Minyak Sereh Dapur (Cymbopogon citratus)
This study evaluated the antifungal activity of lemongrass oil in anti-dandruff gel shampoo formulations and found that a 10% lemongrass oil concentration was the most effective at inhibiting the growth of the dandruff-causing fungus Pityrosporum ovale.
research Dutasteride, a novel dual 5-A reductase inhibitor, reduces serum DHT to a greater extent versus finasteride and achieves finasteride maximal reduction in a larger proportion of patients
Dutasteride reduces DHT more effectively than finasteride.
research Larvicidal potential, antimicrobial properties and molecular docking analysis of Egyptian Mint (Mentha rotundifolia) against Culex pipiens L. (Diptera: Culicidae) and Midgut-borne Staphylococcus aureus
This study found that undiluted mint leaf extract effectively inhibited multidrug-resistant Staphylococcus aureus and killed Culex pipiens larvae, suggesting its potential as a biocontrol strategy around hospitals.
research Experiment on the effect of Artemisia sieversiana extract on hair loss prevention and cell growth
In this study, Artemisia sieversiana extract was found to safely promote hair follicle dermal papilla cell growth and inhibit hair loss through anti-androgen, anti-inflammatory, and antioxidant effects at a cellular level.
research Assessment of Liver Antioxidant Profile in Plasmodium Berghei Infected Mice Treated with Curative Ethanol Leaf extract of Musa paradisiaca
This study evaluated the effects of dry plantain leaf extract on mice infected with Plasmodium berghei, finding that the extract reduced liver oxidative stress associated with the infection.
research Angelica Sinensis and Chinese Arborvitae: A Review on its Phytochemical & Pharmacological Importance
This review examines Angelica sinensis and Chinese arborvitae, highlighting their historical and contemporary use in traditional Chinese medicine and pharmacology. It emphasizes the need for more comprehensive scientific assessments to fully explore their therapeutic potential.
research Araliadiol Protects Human Keratinocytes From Oxidative Stress, DNA Damage, and Apoptosis via Activation of Antioxidant Signaling
This study reported that, in a laboratory setting, araliadiol derived from Centella asiatica activated antioxidant pathways, mitigating urban particulate matter-induced oxidative stress and skin damage.
research HPLC/MS Characterization and Evaluation of the Antioxidant and Anti-Inflammatory Properties of Algerian Medicinal Plant: Carthamus caeruleus L. Extracts
This study found that hydromethanolic extracts from Carthamus caeruleus L. rhizomes exhibited notable antioxidant and anti-inflammatory effects in both in vitro and in vivo experiments, supporting its traditional medicinal uses and suggesting its potential as a source of therapeutic agents.
research Non-competitive androgen receptor inhibition in vitro and in vivo
Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.
research DIETHYLPROPION
This abstract details known indications, categories, and potential reactions for various drugs, including anorexiants, estrogens, NSAID analgesics, cardiac glycosides, and migraine preventives, without reporting new clinical results.
research A review of the botany, ethnopharmacology, phytochemistry, pharmacology, toxicology and quality of Anemarrhena asphodeloides Bunge
This review of Anemarrhena asphodeloides highlights its extensive historical use in Eastern traditional medicine and identifies diverse chemical compounds with numerous pharmacological activities, noting the need for further research to understand its mechanisms and ensure safe use.
research Finasteride, A Steroid 5α-Reductase Inhibitor, Does Not Affect the Oxidative Metabolism of Antipyrine
Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.
research Arachis hypogaea L. Root Extract Mitigates Testosterone Propionate‐Induced Benign Prostatic Hyperplasia in ICR Mice by Suppressing Inflammation, Androgen Receptors, and Dihydrotestosterone
In this study, high-dose Arachis hypogaea root extract significantly reduced prostate weight and markers of glandular hyperplasia in testosterone-induced BPH in mice, with associated changes in inflammatory gene expression and beneficial shifts in gut microbiota.
research Analytical methods of dutasteride: An overview
This study reports that dutasteride, used alone or with tamsulosin, effectively reduces acute urine retention and surgery risk in men with benign prostatic hyperplasia, and may lower prostate cancer incidence, suggesting potential chemopreventive benefits.
research The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific
This study found that dutasteride more effectively inhibited androgen receptor signaling and reduced cell growth compared to finasteride in prostate cancer cell models, with varying sensitivities across different cell lines.
research Dihydromyricetin attenuates fibrosis-associated features of hypertrophic scar with accompanying changes in PI3K/AKT/mTOR-related signaling
This study found that dihydromyricetin may reduce fibrosis features in hypertrophic scars by affecting PI3K/AKT/mTOR signaling, but further research is needed to confirm causality.
research Comparative Study between The Efficacy and Safety of Topical Immune Therapy with Diphenylcyclopropenone versus Anthralin in The Treatment of Resistant Alopecia Areata
This study found that topical DPCP was more effective for hair regrowth in resistant alopecia areata compared to anthralin, with both treatments having similar safety profiles.
research EVALUATION OF ANTI-INFLAMMATORY AND ANTI-ARTHRITIC POTENTIAL OF FRACTIONS OF ECLIPTA PROSTRATA LINN
This study found that the ethyl acetate and chloroform fractions of Eclipta prostrata Linn. exhibited significant anti-inflammatory activity in a carrageenan-induced paw edema model and showed notable anti-arthritic potential in a formaldehyde-induced arthritis model.
research In vivo and in silico evaluation of the ameliorative effect of hesperidin on finasteride-induced testicular oxidative stress in Wistar rats
This study found that in male rats, hesperidin co-administration ameliorated finasteride-induced testicular toxicity by reducing oxidative stress and improving antioxidant status, sperm parameters, and enzyme activity compared to finasteride treatment alone.
research Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry
This study developed a novel method to simultaneously measure finasteride, dutasteride, and related biomarkers in serum, finding that both drugs lowered DHT levels while increasing substrate concentrations.