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No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

SCF and c-Kit decrease in AGA hair follicles, possibly affecting hair pigmentation and growth.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Early diagnosis and treatment are crucial for preventing permanent hair loss in various scalp conditions, and while new treatments are promising, more research is needed to evaluate their effectiveness.

Fibromodulin treatment helps reduce scarring and improves wound healing by making it more like fetal healing.

Female pattern hair loss involves hormonal factors, genetics, and may be linked to low ferritin levels.

The conclusion is that accurately identifying the cause of high androgen levels in women with PCOS is crucial and requires specific tests.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Tedisamil and glibenclamide affect cromakalim and minoxidil sulphate differently in rat aorta.

A study found that minoxidil can damage the hearts of dogs and pigs, cautioning its use in humans.

The conclusion is that measuring how drugs partition into artificial sebum is important for predicting their delivery into hair and sebaceous follicles, and it provides better information than traditional methods.

Finasteride effectively treats male hair loss, improving growth and density.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

The document concludes that while lab results for hair growth promotion are promising, human trials are needed and better testing methods should be developed.

Early hair loss may indicate prostate issues.

Future osteoporosis treatments should focus on increasing bone growth, with many promising options available.

Women generally handle heart enlargement better than men, but it's riskier for them if it occurs; hormones like estrogen offer some protection.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

The document says that understanding the causes of PCOS is important for treatment, especially in distinguishing the syndrome from just having cystic ovaries, and that losing weight is key for obese women with PCOS.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

Severe baldness on the top of the head is linked to a higher chance of heart disease, especially in men under 60.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Laser and light treatments can effectively remove hair long-term.

Method measures minoxidil in tablets accurately and easily.

CRTH2 antagonists might be useful for treating many conditions because they play a role in immune and inflammation responses.

Finasteride can cause sexual problems and depression in young men.

Four patients with a type of rickets and hair loss had different mutations in their vitamin D receptor gene, causing it to not work properly.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.