30 citations
,
March 2015 in “PLoS ONE” This study found that thyroxine modulates peripheral molecular clock gene expression in human hair follicles, which may have implications for treating clock-related diseases in patients with thyroid dysfunction.
34 citations
,
July 2006 in “Clinics in dermatology” This article reviews dermatological manifestations of endocrine diseases in dogs, such as hypothyroidism and hyperadrenocorticism, but reports no new clinical findings.
7 citations
,
October 2020 in “Wiener medizinische Wochenschrift” This paper presents a case study of a 21-year-old male with thyroid hemiagenesis, where the left thyroid lobe and isthmus are absent, and discusses the anomaly's potential clinical consequences based on existing literature.
March 1998 in “Journal of dermatological science” Diphencyprone initially increases mouse hair growth, then slows it, possibly due to changes in specific protein levels.
13 citations
,
September 2022 in “Journal of Animal Behaviour and Biometeorology” This article reviews the thermoregulation mechanisms in African and Asian elephants and highlights challenges from climate change, with no new empirical results presented.
19 citations
,
January 2006 in “Indian Journal of Dermatology” In this study, common skin manifestations in hypothyroidism patients included dry, coarse skin, pigmentary disorders, and telogen effluvium.
26 citations
,
August 2007 in “Annals of Anatomy - Anatomischer Anzeiger” Feathers become harder as they develop due to a change in keratin type.
116 citations
,
April 1986 in “The journal of cell biology/The Journal of cell biology” This study reports that a 190,000 molecular weight protein, identified as trichohyalin, may play a matrix role in the development of inner root sheaths in hair follicles.
46 citations
,
March 2005 in “Endocrinology” In this study, ectoderm-targeted transgenic mice with glucocorticoid receptor overexpression exhibited multiple epithelial defects, suggesting the role of NF-kappaB and p63 dysfunction in ectodermal dysplasia syndromes.
September 2021 in “European Neuropsychopharmacology” This study found that higher dihydrotestosterone (DHT) levels in the parietal region of the scalp may be linked to androgenetic alopecia's clinical presentation.
36 citations
,
February 2018 in “British Journal of Dermatology” In this study, researchers found that eccrine sweat glands in human scalp skin are morphologically integrated into the pilosebaceous unit, suggesting they form a common homeostatic tissue environment with adjacent structures.
39 citations
,
February 1990 in “The journal of cell biology/The Journal of cell biology” This study identified trichohyalin as an early differentiation marker in hair follicles, with potential structural roles related to alpha-helical formations, based on the partial characterization of its cDNA in sheep.
43 citations
,
October 2005 in “Molecular and cellular endocrinology” This review discusses how the CRH/POMC systems may regulate human hair follicle pigmentation and highlights the concept of "self-similarity" in melanocortin systems at both local and systemic levels, without presenting new experimental results.
88 citations
,
August 2014 in “PLOS genetics” This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.
2 citations
,
November 2013 in “Elsevier eBooks” This chapter discusses the role of hormones in regulating reproductive biology and outlines how the endocrine system, particularly the brain and pituitary gland, controls these hormonal processes.
October 2024 in “Journal of the Endocrine Society” In this case report, a 70-year-old woman with a history of autoimmune hypothyroidism experienced alternating hypothyroidism and hyperthyroidism over a decade, highlighting the potential role of thyrotropin receptor autoantibodies in these fluctuations.
This study demonstrates that the trichohyalin gene is located at chromosomal region 1q21, where several other genes related to epidermal differentiation also map.
11 citations
,
January 2020 in “World Journal of Traditional Chinese Medicine” This study used a glucocorticoid-injection model to mimic kidney-yang deficiency syndrome and reported symptoms related to hormonal imbalances in the hypothalamic-pituitary-target gland axes.
72 citations
,
December 2018 in “Journal of Experimental Zoology Part B Molecular and Developmental Evolution” This review provides an overview of the molecular evolution of corneous beta-proteins in reptiles and birds, highlighting their distinct genetic origin and role in epidermal structures, but reports no new results.
14 citations
,
February 2007 in “Irish Veterinary Journal” This study reported the first known case of tertiary hypothyroidism in a dog, diagnosed after a Labrador treated for hyperadrenocorticism presented with related symptoms and an MRI-revealed pituitary mass.
4 citations
,
January 1982 in “Neuroendocrinology” This study found that pimozide, d-butaclamol, and pituitary pars intermedia grafts darken hair color in agouti C3H Avy mice, suggesting dopaminergic inhibition influences peptide-controlled hair color cycling.
January 2001 in “Biomedical Research” This study observed that PAD type III and trichohyalin are expressed earlier than their deiminated form during the first and second hair cycles in rat hair follicles, indicating a potential additional factor is involved in triggering deimination.
September 2024 in “Digital Commons - University of South Florida (University of South Florida)” This study found that injecting various hormones or hormone-cholesterol mixtures into Willow Ptarmigan and White-tailed Ptarmigan led to the growth of pigmented feathers instead of the usual white winter feathers, suggesting hormonal influence on plumage color changes.
17 citations
,
August 2014 in “The Anatomical Record” The researchers reported that scaffoldin, a protein identified in chicken embryos, likely plays a role in forming periderm granules and contributes to the soft cornification of embryonic epidermis.
November 2016 in “Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)” In this study, researchers found that estrogens activate and androgens inhibit brown adipose tissue thermogenesis via the VMH, affecting energy balance and suggesting targets for treating cachexia and obesity.
13 citations
,
November 2007 in “Journal of Structural Biology” Keratin heterodimers are preferred for their specific and structural advantages.
54 citations
,
November 1994 in “Differentiation” This study found that trichohyalin is expressed in various normal and pathological epithelia beyond hair follicle cells, where it is uniquely associated with filaggrin, suggesting a specific role in aggregating K6/K16-containing intermediate filaments.
38 citations
,
July 2004 in “Journal of experimental zoology. Part B, Molecular and developmental evolution” This article discusses a hypothesis on the development and evolution of scales, hairs, and feathers from fish to amniotes, based on regions of dermo-epidermal interactions in skin, but reports no new findings.
15 citations
,
July 2004 in “Journal of morphology” This study analyzes the fine structure and protein distribution in monotreme hairs, finding similarities with other mammals and detailing unique immunocytochemical features in their inner root sheaths.
47 citations
,
July 2005 in “European Journal of Cell Biology” Terrestrial vertebrates have balanced keratin gene clusters, unlike teleost fish.