TLDR The trichohyalin gene is located at chromosomal region 1q21 with other skin-related protein genes.
The study identified that the human trichohyalin gene, a key differentiation product in hard keratinizing tissues, was located at chromosomal region 1q21. This region also contained genes for other structural proteins involved in terminal differentiation in the epidermis, as well as several S-100 class calcium-binding proteins. The mapping was achieved using human-rodent somatic cell hybrids and fluorescent in situ hybridization.
54 citations
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November 1994 in “Differentiation” Trichohyalin is found in non-hair tissues and works with filaggrin in certain skin areas and conditions.
68 citations
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April 2014 in “Journal of Investigative Dermatology” Trichohyalin-like proteins are essential for the development of skin structures like hair, nails, and feathers.
40 citations
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September 2010 in “Journal of Biological Chemistry” Keratin K80 is an ancient protein found in various tissues, important for cell structure and tissue differentiation.
June 2023 in “Historical records of Australian science/Historical Records of Australian Science” George Ernest Rogers was a notable scientist who made important discoveries about hair and wool proteins.
199 citations
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January 2004 in “The International Journal of Developmental Biology” Hair follicle growth and development are controlled by specific genes and molecular signals.