Human Trichohyalin Gene Clustered with Genes for Epidermal Structural and Calcium-Binding Proteins at Chromosomal Locus 1q21
January 1993
Studysummary This study demonstrates that the trichohyalin gene is located at chromosomal region 1q21, where several other genes related to epidermal differentiation also map.
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The study identified that the human trichohyalin gene, a key differentiation product in hard keratinizing tissues, was located at chromosomal region 1q21. This region also contained genes for other structural proteins involved in terminal differentiation in the epidermis, as well as several S-100 class calcium-binding proteins. The mapping was achieved using human-rodent somatic cell hybrids and fluorescent in situ hybridization.
