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research 3α-androstanediol, but not testosterone, attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats
This study found that 3alpha-diol, an androgen metabolite, improved cognitive and affective performance in aged male rats, suggesting its role in countering age-related decline in hippocampally-influenced behaviors.
research Endocrinological evaluation and hormonal therapy for women with difficult acne
This paper discusses hormonal therapy options for women with severe acne, focusing on treatment for cases that do not respond to conventional methods, but it reports no new clinical findings.
research The treatment of acne: The role of combination therapies
research Internet and Social Media Use Among Patients with Hair and Scalp Disorders: A Behavioral Analysis
In this study, dermatologists' TikTok content more frequently recommended standard treatments for hair and scalp disorders compared to influencers, who were more likely to suggest alternative options.
research The Clinical Center’s Blood Glucose Management Service
This article describes how a new blood glucose management service at the NIH Clinical Center improved safety and patient outcomes for hospitalized patients with diabetes.
research Evidence based medicine: a movement in crisis?
This article argues that while evidence-based medicine has provided many benefits, it has also led to negative unintended consequences, and proposes a renewed focus on integrating context and professional expertise to improve patient treatment.
research Circulating sex hormone binding globulin levels are modified with intensive lifestyle intervention, but their changes did not independently predict diabetes risk in the Diabetes Prevention Program
This study found that while intensive lifestyle interventions were associated with favorable changes in SHBG levels due to reduced adiposity, these changes did not consistently predict diabetes risk reduction.
research Psycho-physiologic emergentism; four minds in a body
This overview discusses the mind-body problem and suggests that the brain may be intrinsically part of the mind, processing abstract data without direct interaction, but reports no new research results.
research Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models
This study investigated the effects of ethanol leaf extracts from Ziziphus jujuba and Eclipta alba on cognitive impairments in diabetic rats, finding significant improvements in learning and memory with these treatments, along with decreased blood glucose levels over 21 days.
research INNOVATIVE APPROACHES TO SUPPORTING CLIENTS WITH ALOPECIA: INTEGRATION OF TRICHOLOGY AND BARBERING PRACTICES
research TREATMENT OF REFRACTORY HYPERTENSION
This study found that multiple treatment regimens for refractory hypertension were effective in controlling blood pressure in most patients, with diazoxide being the most effective but least tolerable option.
research SUCCESSFUL 28-DAY COMBINATION THERAPY OF MALASSEZIA DERMATITIS IN A 1-YEAR-OLD MIXED SMALL-BREED DOG: A CASE REPORT
In this case report, combination therapy effectively resolved chronic malasseziosis within 28 days in a small-breed dog from a Southeast Asian tropical climate, with significant symptom improvement and reduced Malassezia density observed by week 4.
research Adverse events of dual anti-seizure medication: Real-life data from a tertiary epilepsy clinic
This study found that dual ASM therapies involving valproic acid were associated with poorer tolerability and specific adverse events, with cognitive side effects occurring prominently across all examined combinations.
research Ichthyosis and Trichothiodystrophy: the Tay and PIBI(D)S Syndromes
This article discusses the history and understanding of Tay syndrome, recognizing it as a distinct condition related to ichthyotic erythroderma, mental retardation, and brittle hair but reports no new clinical results.
research The Off-Label Use of Selective Serotonin Reuptake Inhibitors for Sexual Behavior Management: Risks and Considerations
This review discusses the off-label use of SSRIs to manage inappropriate sexual behavior in elderly dementia patients and highlights the unclear risk of post-SSRI sexual dysfunction, noting a need for high-quality clinical trials.
research SUN-144 Initiating Estradiol Hormone Therapy in a Transgender Woman With Multifocal Idiopathic Localization-Related Epilepsy
In this case report, a transgender woman with refractory epilepsy began estrogen therapy for gender-affirming purposes, experiencing stable epilepsy and reduced gender dysphoria through ongoing multidisciplinary care, highlighting the importance of careful management for similar patients.
research The concept of latent social skills in autism and its predictive value for future development
research Pituitary-dependent hyperadrenocorticism in a terrier dog: A case report
This case report describes a 10-year-old terrier with pituitary-dependent hyperadrenocorticism successfully treated with mitotane.
research Unique Tumor Heterogeneity Within a Single Locally Advanced Basal Cell Carcinoma Resulting in Partial Response Despite Continuous Vismodegib Treatment
This article outlines the scope and content of the Dermatologic Surgery journal, providing an overview without reporting new research results.
research Hairy tongue associated with the use of baricitinib therapy for ophiasis pattern alopecia areata
In this report, a young Caucasian woman developed a hairy tongue as an unusual side effect during baricitinib therapy for severe alopecia areata, which was managed by daily toothbrush debridement.
research Wnt/β-Catenin Signaling Stabilizes Hemidesmosomes in Keratinocytes
This study found that inhibiting Wnt/β-catenin signaling disrupted hemidesmosome organization in keratinocytes, suggesting potential therapeutic targets for HD-defective diseases like epidermolysis bullosa.
research Dysmorphic Concern Questionnaire: Greek Translation, Validation and Psychometric Properties
This study concludes that the Greek version of the Dysmorphic Concern Questionnaire is a reliable and valid tool for assessing body dysmorphic disorder-related concerns in both research and clinical settings.
research Nutrition and Emotional Health Education: The Use of Emotional Intelligence and a Plant-Based Diet to Reduce Cardiometabolic Risk
In this study, the authors reported preliminary evidence that programs combining nutrition and exercise interventions can significantly reduce BMI and LDL levels, suggesting these elements are important for lifestyle modification.
research 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane
In this study, TCDD administered to male rats down-regulated EGF receptor in liver plasma membranes and increased protein kinase activity, suggesting EGF receptor–mediated toxicological effects.
research 5-Alpha Reductase Inhibitors on Hypersexuality During the Manic Phase of Bipolar and Psychotic Patients; New Insight to a Well-Known Medicines
research Simultaneous Target-Mediated Drug Disposition-Pharmacodynamic (TMDD-PD) Modeling of Finasteride and Dutasteride: Impact of Target Binding and Turnover on Non-linear Pharmacokinetics
Finasteride and dutasteride's effects are mainly due to target binding saturation and slow enzyme turnover.