Unique Tumor Heterogeneity Within a Single Locally Advanced Basal Cell Carcinoma Resulting in Partial Response Despite Continuous Vismodegib Treatment

    July 2018 in “ Dermatologic Surgery
    Priya Mahindra Nayyar, Anne Lynn S. Chang, Kavita Y. Sarin, Désirée Ratner
    TLDR Different tumor cells in one basal cell carcinoma can cause mixed treatment responses, suggesting personalized treatment is needed.
    The document discussed a case of tumor heterogeneity within a single locally advanced basal cell carcinoma that resulted in a partial response to continuous Vismodegib treatment. This highlighted the complexity of treating basal cell carcinoma due to the presence of diverse tumor cell populations within the same tumor, which can lead to varied responses to treatment. The study underscored the need for personalized treatment approaches in managing such cases to improve therapeutic outcomes.
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