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In this study, researchers developed a sensitive assay to measure the inhibition of steroid 5-α reductase (5AR) by chemicals like finasteride and dutasteride, revealing species-specific differences in inhibitor efficacy between human and fish cell lines.

This study found that young women with female-pattern hair loss exhibit increased testosterone production rates while dihydrotestosterone production rates remain within or below the normal range.

This study found that taking a daily oral dose of 50mg DHEA for one year had no significant impact on blood lipids, insulin sensitivity, or the endometrium in postmenopausal women with low libido.

In this case report, researchers describe a 13-year-old phenotypic female with 46,XY karyotype, previously misdiagnosed with androgen insensitivity syndrome, who was later identified to have 17-beta-hydroxysteroid dehydrogenase type 3 deficiency, underscoring the importance of genetic and hormonal tests for accurate diagnosis of sex development disorders.

This study demonstrated that the differential wetting characterization (DWC) method can effectively differentiate changes in the wetting properties of hair fibers after chemical or physical treatment.

This study developed a validated gas chromatography–tandem mass spectrometry assay to assess sex steroid hormones in cerebrospinal fluid, finding substantial levels of DHEA, androstenedione, and testosterone, with strong correlations to serum levels, providing insight into sex steroid dynamics in the human CNS.

This chapter reviews recent advances in 5α-reductase inhibitors for treating disorders mediated by dihydrotestosterone and reports no new clinical findings.

This study evaluated the potential toxicity of oral dihydroartemisinin in SD rats, finding that female rats experienced greater toxic effects than males, particularly at higher doses, but these effects were reversible after a 4-week recovery period.

Adjusting hair dryer settings improves drying efficiency and keeps hair healthy.

This study found that relatively low concentrations of 1,25(OH)2D3 stimulated human hair follicle and fiber growth, while higher concentrations inhibited growth in a whole-organ culture system.

This study found that DHEAS levels were lower in anti-TPO Ab positive PCOS patients compared to those who were negative, indicating a possible link between autoimmunity and reduced DHEAS in these patients.

The authors concluded that increased expression of the HSD11B1 gene in adipose tissue correlates with obesity markers and predicts insulin resistance, but this association is independent of polycystic ovary syndrome when adiposity is controlled for.

This study developed a high-resolution phototrichogram system that can automatically and accurately assess hair growth metrics in cosmetic trials, achieving over 90% correlation with manual measurements.

This study found that androgenetic alopecia in men is associated with significant psychological distress and moderate depression, suggesting a possible link between raised dihydrotestosterone levels and mental health issues.

This study observed that hirsute females displayed increased S-phase hair bulb cells and decreased G0/1-phase cells compared to healthy females, with a strong correlation between S-phase percentages and DHEA-S levels.

This article discusses the potential role of oral DHEA, available as a 'dietary supplement' in the US, in COVID-19 morbidity and mortality, calling for clinical trials to assess its safety.

Direct-to-consumer teledermatology is not effectively reaching underserved populations due to language, technology, and insurance barriers.

This study found that improved testosterone measurement using LC-MS/MS in women with PCOS revealed a stronger correlation between hyperandrogenism and insulin resistance than previously detected.

This study suggests that 5-ADIOL-S may contribute to the synthesis of potent androgens in peripheral tissues, and 3 alpha-DIOL-S could be a marker of androgen metabolism in various female patient groups.

This study found that the protein hairless acts as both a corepressor and coactivator of the vitamin D receptor, influencing gene transcription in a ligand-selective manner.

This study suggests that hair analysis could serve as a diagnostic tool for detecting calcium channel activity, which influences hair calcium levels and may indicate calcium deficiency or related disease states.

This study found a weak positive correlation between dihydrotestosterone levels and C-reactive protein in COVID-19 patients, particularly in those with low testosterone, suggesting potential inflammatory effects.

In this study, insulin resistance was observed at similar rates in non-obese women with idiopathic hirsutism, those with PCOS, and healthy controls.

This review examines the methods and challenges in androgen laboratory diagnostics, discussing their advantages, limitations, and evolution; it presents no new experimental results.

This study found that nuclear androgen receptor levels varied among females with androgen-dependent dermatoses, being highest in hirsutism, which may suggest superior androgen stimulability compared to acne and androgenetic alopecia.

Testosterone, DHT, and estradiol significantly affect hair cell growth.

The body's change of testosterone into DHT is not necessary for testosterone's muscle and sexual effects.

This study suggests that decreased levels of dihydroceramide in hair may serve as a biomarker for the progression of alopecia.

This study found diverse responses to the androgen dihydrotestosterone in rodent tissues, with most androgen-regulated processes being specific to particular tissues.