Dehydroepiandrosterone Sulfate Level Is Lower in Polycystic Ovary Syndrome Patients with Autoimmune Thyroid Disease

In 2015, a study was conducted on 59 patients with Polycystic Ovary Syndrome (PCOS) and 28 control subjects to evaluate the level of Dehydroepiandrosterone sulfate (DHEAS) in PCOS patients with Autoimmune Thyroid Disease (AITD). The study found no significant difference in the levels of TSH, fT4, and DHEAS between the PCOS patients and controls. However, serum anti-TPO Ab and anti-Tg Ab levels were significantly higher in the PCOS group. A significant negative relationship was observed between DHEAS and anti-TPO Ab levels. The DHEAS level was significantly lower in anti-TPO Ab positive PCOS patients. The study concluded that AITD was more prevalent in PCOS patients and the low DHEAS levels in some PCOS patients could be explained by autoimmunity.