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This abstract reviews testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production and reports no new research findings.

This study found that altered testosterone metabolism and changes in cytochrome P450 mono-oxygenase expression are significantly associated with cardiac hypertrophy in human hearts and spontaneously hypertensive rats.

This review discusses testosterone metabolism in human skin and its role in androgenetic skin disorders, suggesting that temporary increases in dihydrotestosterone may lead to these conditions.

This study found that 4 weeks of finasteride treatment significantly decreased DHT levels in bald scalp to levels similar to hair-containing scalp in men with male pattern baldness.

This study found that testosterone-enanthate increased red blood cell production and altered iron homeostasis in older hypogonadal men without being affected by finasteride, indicating these effects do not require type II 5α-reductase enzyme activity.

Testosterone needs to be converted to DHT to reduce stress response in male rats.

This study found that testosterone is converted to estrogenic steroids in vitro without aromatase involvement, suggesting that combining 5α-reductase and aromatase inhibitors might reduce estrogenic steroids more completely in vivo.

This article summarizes findings on the role of androgens and estrogens in male reproductive tissues across species, highlighting the roles of hormone metabolism, receptor distribution, and stress-induced changes.

This review discusses testosterone metabolism in human skin and its link to androgenetic alopecia, acne vulgaris, and idiopathic hirsutism, but it presents no new results.

In this study, dihydrotestosterone increased proliferation and decreased IL-6 production in in-vitro fibroblasts from hereditary gingival fibromatosis and normal gingiva, effects partially reversed by anti-androgens.

This study suggests 5α‐androstan‐3α‐17β‐diol may be the true inducer of kidney enzymes in certain mice, while its induction mechanism likely involves pinocytosis rather than a receptor protein.

This study found that Bokusoku extract and its compound pentagalloyl glucose inhibited testosterone metabolism and sebum synthesis, suggesting potential therapeutic use for androgen-related acne.

In this study, petroleum ether extract of Citrullus colocynthis fruit effectively promoted hair growth in a mouse model of androgen-induced alopecia, showing comparable results to the standard treatment, finasteride.

This article reviews the role of 5α-reductase in cutaneous hyperandrogenism and the potential of 5α-reductase inhibitors and antiandrogens in treating conditions like hirsutism and male-pattern baldness, reporting no clinical results.

This study found that white wax and its extract may promote hair growth in a mouse model of androgenetic alopecia by inhibiting 5α-reductase activity and increasing cell proliferation, with efficacy surpassing finasteride.

This study found that Cacumen platycladi extract significantly promoted hair growth and reduced dihydrotestosterone levels by inhibiting 5α-reductase activity in an androgen-sensitive mouse model.

In this study, the authors concluded that androgens, but not estrogens, strictly mediate the maintenance of neuromuscular morphology in the spinal nucleus of the bulbocavernosus in adult rats.

In this study, high concentrations of dihydrotestosterone and testosterone reduced the growth of human hair follicle cells in vitro, while high estradiol levels increased their growth.

This study found that dutasteride completely suppressed the formation of 5alpha-dihydro metabolites in cultured human skin cells, suggesting its potential use in acne and androgenetic alopecia.

This study found a direct correlation between the testicular feminization gene and decreased androgen receptor activity, potentially explaining the androgen insensitivity in affected individuals.

This study found that low serum testosterone and elevated serum oestrone in men with cirrhosis are associated with worse liver disease and adverse health outcomes, suggesting oestrone as a potential ill health marker.

This study found that young women with female-pattern hair loss exhibit increased testosterone production rates while dihydrotestosterone production rates remain within or below the normal range.

This case study reports that hormonal imbalances in a young boy with precocious pseudopuberty returned to normal after the removal of a testicular interstitial cell tumor, with normal spontaneous puberty following.

This study found that MENT is 10 times more potent than testosterone in suppressing gonadotropins and contributing to anabolism in monkeys, with a potentially wider therapeutic index for human androgen replacement and male contraception.

In this study, topical EGCG significantly reduced testosterone-induced hair loss and follicular apoptosis in mice, without altering testosterone or dihydrotestosterone concentrations.

This study found that prostate cancer aggressiveness in men with obesity is associated with changes in age, BMI, testosterone, and estradiol levels, and that adipocyte-secreted molecules increase cancer cell aggressiveness in vitro.

In this study, testosterone and certain metabolites were highly effective in promoting sebaceous structure growth in the female hamster flank organ, while others had limited or no effect.

This study found that administering testosterone to ovariectomized female rats decreased endometrial tight junction complexity and expression of specific proteins, potentially affecting embryo implantation.

This study found that canine dermal papilla cells and fibroblasts metabolize androgens differently than human hair follicle cells, indicating species-specific differences in androgen metabolism.

Testosterone, DHT, and estradiol significantly affect hair cell growth.