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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

The Rotterdam Study aims to understand various diseases in older adults.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Low fluence photoepilation temporarily removes hair by targeting the hair follicle's pigmented area without severe damage.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Finasteride may cause slight depression and anxiety.

Men over 66 taking medication for prostate enlargement have a higher risk of depression and self-harm, especially in the first 18 months of treatment.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Acne treatment varies, with topical and systemic therapies effective, and more research needed on treatment order and long-term effects.

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Beta-caryophyllene helps improve wound healing in mice, especially in females.

Low doses of mixed chemicals cause permanent reproductive malformations in male rats.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

Plant-based ingredients are effective and safe for modern skincare products.

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

Herbal nano-formulations show potential for effective skin delivery but need more research.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Sex hormones affect brain injury differently in males and females.

A natural steroid in the body may protect against eye damage in glaucoma.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.

Stress worsens Tourette symptoms by increasing allopregnanolone levels.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

Sonidegib and vismodegib are similarly effective for advanced basal cell carcinoma, but sonidegib might have a slightly better safety profile.

A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Finasteride reduces response to stress and rewards, affecting behavior and mental health.