2 citations
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January 2016 in “SANGYO EISEIGAKU ZASSHI” This study found that nearly all nurses caring for chemotherapy patients showed detectable levels of cyclophosphamide in their urine, indicating significant occupational exposure to this antineoplastic drug.
December 2023 in “Journal of materials chemistry. B” This study found that a nanoemulsion containing perfluorooctyl bromide effectively increased oxygen levels in an anoxic environment, enhancing hair dermal papilla cell growth and significantly promoting hair organ elongation.
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that while 450nm blue light can inhibit collagen and induce oxidative stress in dermal fibroblasts, 850nm near-infrared light may enhance metabolic activity without causing oxidative damage, suggesting potential for tailored light therapies in skin treatments.
November 2025 in “The Journal of Immunology” In this study, researchers observed elevated levels of epidermal γδ T cells, keratinocytes, and an upregulation of the BST2 gene among immune cells in C3H/HeJ mice with alopecia areata, suggesting a potential role in disease pathogenesis.
66 citations
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February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” The researchers reported that adenosine increases FGF-7 expression in dermal papilla cells, which may stimulate hair growth via the A2b adenosine receptor and cAMP pathway.
48 citations
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June 2013 in “Journal of Dermatological Science” This study found that valproic acid promoted human hair growth by increasing β-catenin levels, suggesting it may be a potential therapeutic option for alopecia.
1 citations
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June 2013 in “Science-business Exchange” In this study, researchers at the University of Pennsylvania found that increasing FGF9 levels in wounded mouse skin can lead to the growth of hair follicles.
January 2026 in “MEDS Clinical Medicine” This review highlights emerging evidence that biophysical and metabolic cues, such as oxygen levels and tissue mechanics, significantly influence skin stem cell behavior, which is crucial for developing advanced wound healing therapies beyond traditional infection and inflammation control.
January 2025 in “International Journal of Veterinary Science” In this animal study, hibiscus leaf simplicia ointment was found to protect red blood cell levels and promote better hair growth in UV-exposed rats, though it did not maintain normal skin histology; the ointment showed no significant acute dermal toxicity.
December 2016 in “Experimental and Molecular Pathology” This study found that the wild-derived mouse strain Mus pahari has fragile skin that separates at subdermal levels under moderate force, potentially due to altered extracellular matrix development.
October 2025 in “Journal of the Endocrine Society” In this case report, an 80-year-old woman experienced elevated alkaline phosphatase levels due to the use of Viviscal hair supplements. Her levels returned to normal after discontinuing the supplement, highlighting the need for clinicians to consider supplements as potential causes of abnormal lab results.
September 2011 in “Clinical Biochemistry” This review discusses the relationship between vitamin K and osteoarthritis, noting that while lower vitamin K levels are associated with increased osteoarthritis, the effects of vitamin K supplementation on the condition remain unclear due to a lack of clinical trials.
171 citations
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July 2007 in “Journal of Investigative Dermatology” The researchers reported that DHT-inducible DKK-1 may play a significant role in DHT-driven balding by inhibiting hair follicle cell growth and promoting apoptosis in androgenetic alopecia.
72 citations
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January 1983 in “The Anatomical Record” This study found that epidermal growth factor treatment in male mice delayed normal skin development, inhibiting hair growth and follicle development by maintaining birth-level cell proliferation and differentiation for several days.
47 citations
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July 2004 in “Journal of Dermatological Science” In this study, decreased expression of BMP2 and ephrin A3 and increased NT-4 gene expression were observed in dermal papilla cells from androgenic alopecia-affected skin, suggesting potential roles in hair growth regulation.
42 citations
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September 2015 in “Gene” This study demonstrated that FGF5s acts as an inhibitor of FGF5 in regulating hair growth cycles in cashmere goat dermal papilla cells.
30 citations
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October 2014 in “Experimental Dermatology” This study found that leptin from dermal white adipose tissue may regulate hair growth and cycle progression through its receptor on hair follicle epithelium in mice and humans.
28 citations
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August 2019 in “BMC Genetics” This study identified a target relationship between miR-148a, miR-10a, and BMP7, suggesting these microRNAs influence dermal papilla cell proliferation and may regulate hair follicle growth.
24 citations
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March 2001 in “Journal of Endocrinology/Journal of endocrinology” In this study, androgen receptors were found only in the mane follicles of red deer stags during the breeding season, suggesting their expression is induced by seasonal hormone changes.
23 citations
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September 2011 in “Journal of Dermatological Science” This study explored the effects of a new narrow-band red LED light on hair growth in mice, showing potential benefits compared to existing laser therapies.
19 citations
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February 2018 in “Nutrients” This review discusses the relationship between zinc deficiency and skin disorders, emphasizing zinc transporters' roles, but it reports no new clinical results; the authors highlight potential benefits of regulating zinc levels via transporters.
16 citations
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August 1996 in “The journal of experimental zoology/Journal of experimental zoology” This study suggests that red deer stags provide a novel model for investigating hormonal regulation of hair growth due to the different cell growth rates in hair follicles during breeding and nonbreeding seasons.
15 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” In a C3H mouse model, this study found that topical retinoids can significantly alter hair-cycle dynamics by prolonging the anagen phase and shortening the telogen phase, a reaction connected to increased cellular retinoic acid-binding protein levels.
12 citations
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June 2022 in “International Journal of Molecular Sciences” In this study, copper was found to promote the proliferation of dermal papilla cells in Rex rabbits by maintaining the function of the cellular mitochondrial electron transport chain.
9 citations
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July 2020 in “Cell Proliferation” In this study, EREG promoted hair growth by activating specific receptors in cell and animal models, indicating it may be a potential treatment for hair loss.
6 citations
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March 2020 in “Scientific reports” This study found that glucose metabolism supports hair inductive gene expression and hair shaft elongation in dermal papilla cells, suggesting potential applications for in vitro hair follicle generation.
6 citations
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January 2022 in “Journal of Investigative Dermatology” This study found that androgen receptor signaling is linked to blood vessel regression in the dermal papilla of balding scalp, contributing to hair follicle miniaturization in androgenetic alopecia.
5 citations
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October 2024 in “International Journal of Biological Sciences” This study found that a specific fragment of AIMP1, secreted by hair follicle stem cells, activated dermal papilla cells, leading to enhanced hair regrowth and maintenance in mice.
3 citations
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December 2022 in “Nutrients” This study found that limonin may promote hair growth by enhancing anagen signaling through autophagy activation in rat dermal papilla cells, suggesting its potential as a natural treatment for hair loss.
3 citations
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August 2018 in “Stem cells international” This study found that cultured hair follicle dermal cells support maintenance and potentially aid in the clinical application of pluripotent and haematopoietic stem cells.