September 2023 in “Clinical, cosmetic and investigational dermatology” This case series reports successful treatment of refractory folliculitis decalvans using surgical excision with second-intention healing and guarded high-tension suturing, resulting in long-term remission without recurrence over a 10–24 month follow-up period.
5 citations
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March 2014 in “Journal of The American Academy of Dermatology” The study suggests hormonal factors may play a role in Frontal Fibrosing Alopecia and that treatments like oral antiandrogens and steroids could be beneficial.
November 2021 in “International journal of biology, pharmacy and allied sciences” This study found that air pollution and dust particles are major contributors to hair fall among young adults living in urban areas.
December 2025 in “Actas Dermo-Sifiliográficas” This consensus from 22 Spanish dermatologists recommends using a multimodal therapy starting with oral dutasteride, combined with topical and/or intralesional agents, and adding hydroxychloroquine if inflammation persists, to manage frontal fibrosing alopecia due to its irreversible hair loss and lack of specific approved treatments.
195 citations
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November 2001 in “The Journal of Cell Biology” This study found that desmocollin 1 is crucial for strong adhesion and barrier maintenance in the mouse epidermis, with its absence leading to skin and hair issues resembling chronic dermatitis.
7 citations
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March 2017 in “Annals of Plastic Surgery” In this study, researchers developed a new variant of the Mercedes flap with releasing incisions for reconstructing medium-sized scalp defects, demonstrating complete defect closure without complications in three patients following a single operation with excellent aesthetic outcomes.
4 citations
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April 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)” This review highlights available treatments for frontal fibrosing alopecia, noting that 5-alpha reductase inhibitors, intralesional steroids, and hydroxychloroquine currently have the most evidence supporting their use, while other treatments show variable results and require further study.
This study found that Fraser's Dolphin, a tight-skinned mammal, can regenerate complex skin architecture with minimal scarring after large full-thickness wounds, even in high-tension environments, offering insights into regenerative healing mechanisms typically obscured by fibrotic responses.
1 citations
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August 2018 in “Journal of the American Academy of Dermatology” A young woman developed facial bumps before hair loss, which is unusual for her condition.
15 citations
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June 2019 in “Biochemical Journal” This study identified a heterozygous de novo mutation in the ODC1 gene causing a new disorder characterized by overgrowth and developmental delay, and suggests that DFMO treatment may help manage elevated ODC activity and putrescine levels.
April 2025 in “Australasian Journal of Dermatology” This report presents the first Australian case of familial frontal fibrosing alopecia involving a mother and daughter and seeks to differentiate clinical features between familial and sporadic cases.
28 citations
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January 2022 in “PLoS ONE” This study reports that a sarcoptic mange outbreak, likely originating from mange-infected llamas from a governmental program, dramatically reduced vicuña and guanaco populations in San Guillermo National Park, Argentina.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that allergens like linalool found in personal care products may contribute to the pathobiology of frontal fibrosing alopecia by affecting immune responses and stem cell function in hair follicles.
2 citations
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January 2024 in “Journal of Pharmacognosy and Phytochemistry” The study highlights Teak's (Tectona grandis) diverse applications beyond high-quality timber, emphasizing its bioactive compounds' pharmacological potential in cancer treatment and other uses across traditional medicine, cosmetics, and biodiesel production.
Miniflap hair restoration is a method to regrow hair.
October 2023 in “Al-Kauniyah” In this study of gibbons at the Tegal Alur Animal Rescue Center, researchers found that while the feeding schedule met natural requirements, the gibbons' body weights were lower compared to their counterparts in the wild, and some exhibited hair loss and depigmentation.
August 1998 in “Dermatologic Surgery” Dr. George A. Farber recommends using follicular unit transplantation for hair restoration because it gives a more natural look and has fewer problems compared to the older miniflap technique.
December 2024 in “JAPI (Jurnal Akses Pengabdian Indonesia)” This study found that a community education program using group discussions and leaflets significantly increased knowledge and skills among Sungai Bilu residents in South Kalimantan for using riverbank plants as alternative medicine.
January 2014 in “Revista del Hospital Juárez de México” The authors concluded that preoperative treatment with finasteride for a month effectively reduced perioperative bleeding and shortened hospital stays in patients undergoing transurethral resection of the prostate.
8 citations
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September 2011 in “European Journal of Dermatology” This study reports that most cases of frontal fibrosing alopecia did not show significant improvement with available treatments, and effective management remains unproven.
1 citations
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October 2025 in “Journal of Investigative Dermatology” In this study of women with frontal fibrosing alopecia, delgocitinib cream improved the molecular signature of lesions and demonstrated potential as a treatment, showing significant transcriptomic changes and some clinical improvements over 12 weeks compared to a cream vehicle.
20 citations
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February 2018 in “Journal of the European Academy of Dermatology and Venereology” This study reported that applying a cream with 5% vitamin C reduced dermatoporosis-related purpura, suggesting the condition may be linked to vitamin C deficiency.
19 citations
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March 2023 in “Resources” This review discusses the potential of solid-state fermentation for extracting polyphenolic compounds from agro-industrial wastes, but it reports no new experimental results.
7 citations
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August 2019 in “American Journal of Dermatopathology” This study found that limb hair loss in frontal fibrosing alopecia is inflammatory and permanent, but lacks the classic scarring features seen in scalp alopecia, prompting potential misdiagnosis as alopecia areata.
19 citations
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January 2014 in “Facial plastic surgery” This review discusses the mechanisms and effects of dermabrasion for improving skin appearance and reports no new clinical results.
34 citations
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June 2020 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, researchers observed that follicular damage and stem cell loss in frontal fibrosing alopecia may be mediated by immune attacks at the bulge region, suggesting potential for JAK/STAT-targeting treatments to prevent progression.
February 2026 in “Contact Dermatitis” This study reports a case of phytodermatitis in a 58-year-old male due to exposure to Axonopus compressus, commonly known as carpet grass, during open defecation, highlighting an unusual cause of contact dermatitis linked to sanitation practices.
1 citations
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March 2024 in “International Journal of Dermatology” This case report describes a therapy-resistant folliculitis decalvans patient who showed nearly complete response with increased hair density after treatment with CO2 laser-assisted photodynamic therapy.
2 citations
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July 2022 in “Frontiers in Medicine” This review discusses the current understanding of frontal fibrosing alopecia's pathogenesis, highlighting genetic susceptibility, immune response involvement, and possible links to steroid hormones, but reports no new clinical results.
1 citations
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January 2018 in “Medical Science and Discovery” This review examines the characteristics of frontal fibrosing alopecia in postmenopausal women, highlighting the importance of biopsy for early diagnosis and potential treatment to prevent disease progression.