Dermatoporosis: A Further Step to Recognition

The study by Humbert et al. focused on treating Bateman purpura, a sign of dermatoporosis, with topical vitamin C, suggesting that the condition might be linked to vitamin C deficiency. Dermatoporosis, a chronic skin fragility syndrome, was prevalent in the elderly, affecting 32% to 37.5% of older adults in French studies. It manifested as skin atrophy, senile purpura, and pseudoscars, primarily in sun-exposed areas. The study highlighted the role of hyalurosome deficiency in dermatoporosis, with potential interventions targeting CD44/HA pathways. Topical hyaluronic acid fragments (HAF) and retinaldehyde (RAL) showed promise in reversing skin atrophy and improving skin condition. The research suggested that vitamin C might have pharmacologic effects on molecular targets in dermatoporosis, making it a potential ingredient in topical treatments.