January 2017 in “Elsevier eBooks” This article reviews skin toxicities caused by radiation in metastatic cancer patients and discusses preventive measures, highlighting that current interventions lack robust supporting data.
January 2016 in “Kafkas Journal of Medical Sciences” This study observed that dermatologists predominantly prescribed topical treatments for skin disorders in pregnant women, with pruritus and urticaria being the most common conditions.
March 2013 in “Journal of pediatric nursing” This case report presents a 14-year-old girl with type A insulin resistance, illustrating diagnostic processes to differentiate it from type 2 diabetes in the context of pediatric obesity and hyperglycemia.
January 2011 in “Revista Portuguesa de Endocrinologia Diabetes e Metabolismo” This article presents a case of congenital adrenal hyperplasia and myelolipoma in a 56-year-old woman, describing her symptoms and characteristics without offering new clinical results.
November 2009 in “Companion Animal” The document suggests that Alopecia X in dogs is mainly a cosmetic issue and might be better left untreated.
January 2021 in “Journal of clinical and cosmetic dermatology” This review highlights the role of the skin's photosensory system in mediating responses to UVA radiation, contributing both to immediate protective effects and to broader circadian and seasonal adaptations, but reports no new experimental results.
64 citations
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June 1992 in “International Journal of Dermatology” Pregnancy often causes skin changes like darkening, stretch marks, and hair growth, which may improve after childbirth.
16 citations
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February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
3 citations
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August 2023 in “The Journal of Pediatrics” Sodium valproate can rarely cause skin darkening, which may improve after stopping the drug.
14 citations
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March 2016 in “Cutaneous and Ocular Toxicology” This study observed that SC users commonly exhibited dermatological findings like periorbital darkening and blade scars, highlighting the importance for dermatologists to recognize these markers for early diagnosis and intervention.
12 citations
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May 2018 in “JAAD Case Reports” This case report describes a patient with psoriasis who experienced scalp hair darkening and increased growth during anti–IL-17 therapy.
In this case study, a patient experienced darkening of hair color after taking acitretin, an oral retinoid known for potentially causing alopecia, marking a rare and undocumented phenomenon.
January 2015 in “Journal of cosmetology & trichology” In this pilot study, eyebrow mesotherapy was reported to achieve clinically apparent thickening and darkening of eyebrows, with 8 out of 12 patients satisfied with the results after 15 days.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study developed a natural herbal shampoo using curry leaves as the main ingredient, combined with other natural substances, aiming to enhance hair growth, strength, and natural darkening while reducing hair loss without the risks associated with chemical shampoos.
April 2023 in “International Journal of Science and Research (IJSR)” This study focuses on developing a natural herbal shampoo using pomegranate peels and other plant-based ingredients to enhance hair growth, strength, and darkening while maintaining safety and efficacy compared to chemical-based alternatives.
July 2022 in “International Journal of Health Sciences (IJHS)” This study found that skin changes such as pigmentary alterations, vascular and connective tissue changes are common during pregnancy, with areola/nipple darkening and striae gravidarum frequently observed.
June 2021 in “Clinical neuropsychopharmacology and therapeutics” This paper reviews the hair color changes associated with valproic acid treatment, noting only a few reported instances of bleaching or darkening, and reports no new findings.
74 citations
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July 1995 in “PubMed” This study suggests that reversible hypopigmentation in homocystinuric patients may result from tyrosinase inhibition by homocyst(e)ine, with in-vitro experiments showing copper sulfate reversing this inhibition.
71 citations
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February 2006 in “Clinics in Dermatology” This review discusses the physiological skin changes during pregnancy and reports no new clinical results, emphasizing the importance of distinguishing these changes from pathological conditions.
23 citations
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November 2007 in “Actas Dermo-Sifiliográficas” This study suggests that topical T3 can induce hair follicles to enter the growth phase and may reverse graying in mice, with in vitro results supporting enhanced hair shaft growth.
20 citations
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February 2010 in “Journal of Investigative Dermatology” Slug (Snai2) helps regulate hair growth timing in mice.
9 citations
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December 2010 in “Journal of The European Academy of Dermatology and Venereology” This letter reports repigmentation of hair in patients receiving latanoprost therapy.
2 citations
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November 2024 in “JAAD reviews.” This review reported that certain systemic drugs, including antiepileptics and anticancer drugs, can lead to changes in hair pigmentation, such as hypopigmentation or hyperpigmentation, with varied prevalence and clinical characteristics.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, researchers formulated a herbal hair dye with natural ingredients, including Barleria prionitis, and found it to be stable, effective, and a promising natural alternative to chemical dyes, enhancing color intensity and hair conditioning compared to formulations without this component.
December 2025 in “JEADV Clinical Practice” This case study reports on a 72-year-old woman with frontal fibrosing alopecia and hair repigmentation, suggesting the rare occurrence of canities reversal could aid in diagnosing FFA.
January 2024 in “CRC Press eBooks” This study discusses the potential of microbial exopolysaccharides as safer cosmetic ingredients compared to synthetic chemicals like parabens and BHA, which may cause skin damage and cancer; exopolysaccharides offer benefits like antimicrobial and antioxidative effects without harmful impacts.
This article discusses localized repigmentation of hair, suggesting it may be an indicator of underlying melanoma, and emphasizes the need for careful diagnostic evaluation.
January 2010 in “Xiandai yaowu yu linchuang” In this mouse study, Yangxue Shengfa Capsules were associated with promoted hair growth by increasing VEGF levels, hair follicle number, and skin blood vessels.
A woman successfully sued for not being told about a medication's side effects, emphasizing doctors' duty to inform patients.
39 citations
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March 2009 in “Dermatology Online Journal” This review observes that trichomegaly, a newly described side effect of EGFR inhibitors causing excessive eyelash and scalp hair growth, persists in some patients whose tumors respond positively to the therapy.