45 citations
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March 2020 in “ACS Applied Materials & Interfaces” In this study, researchers created a novel fibrous membrane inspired by ancient Chinese medicine that effectively promotes hair follicle regeneration and wound healing in deep burn injuries by releasing quercetin, copper, and silicon ions.
25 citations
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June 1998 in “Biological Trace Element Research” This study found that young healthy women with a family history of noninsulin-dependent diabetes mellitus exhibited higher zinc and lower copper concentrations in hair compared to those without such a family history, suggesting a possible Cu-Zn antagonism.
11 citations
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September 2012 in “Chinese science bulletin/Chinese Science Bulletin” This study found that variations in mineral content of hair, such as increased Zr in asthma and respiratory infections, may be linked to different illnesses, suggesting potential diagnostic use.
9 citations
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January 2013 This study found that serum levels of zinc, copper, and selenium were significantly lower in patients with alopecia areata compared to healthy controls, regardless of the number of hair loss patches.
1 citations
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August 2015 in “PubMed” This study discovered previously unknown structures in human hair shafts that may stabilize hair structurally and physicochemically.
March 2025 in “American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology” This study observed that individuals with hair loss had significantly higher levels of serum galanin, troponin, prolactin, and FSH, and lower levels of TSH, zinc, magnesium, copper, iron, and calcium compared to healthy controls, suggesting a potential role of these biomarkers in hair loss.
June 2024 in “Research Square (Research Square)” This study found that women experiencing hair loss post-COVID-19 showed significantly decreased serum copper levels, suggesting potential further research into copper supplementation for preventing and treating post-COVID-19 alopecia.
January 2022 in “Bio web of conferences/BIO web of conferences” This study concluded that the elemental composition of tail brush hair in newborn calves can indicate trace element supply to the fetus during the last months of pregnancy.
June 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that a synthetic polyphenol, dimeric 1,2,4-benzenetriol (diBTO), can coat gray hair and gradually oxidize, creating a resistant brown layer similar to apple browning, which offers a practical hair dyeing solution that withstands washing and reduces the need for long dyeing sessions.
March 2004 in “Journal of Investigative Dermatology” Razor bumps are linked to a genetic variant, misoprostol helps erythromelalgia pain, steroid ointments don't affect skin rhythms, and certain antibodies are common in localized scleroderma.
165 citations
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January 2008 in “Journal of biomaterials science. Polymer ed.” This review outlines the various processes activated by the peptide GHK-Cu in tissue remodeling and reports improvements in skin and wound healing but notes a need for further study to fully understand these mechanisms.
15 citations
,
July 2012 in “Biological trace element research” This study found that an increased calcium/magnesium ratio in hair and lower chromium concentration were associated with higher insulin resistance in Korean adult males.
13 citations
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July 2017 in “Annals of Oncology” This study suggests that DNA-neutralizing agents like DNAse I and Resveratrol-Cu might reduce chemotherapy-induced toxicity, although this conclusion is based on a small animal study and needs more research.
2 citations
,
November 2023 in “Bioactive materials” The researchers reported that a newly developed ionic liquid-based microemulsion significantly improved the local delivery of copper peptides in mice, enhancing hair growth-related factor activation while offering a safer, non-invasive alternative to existing treatments for hair loss.
1 citations
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December 2023 in “Nanomaterials” In this study, the researchers synthesized copper-doped mesoporous silica nanoparticles and observed that they enhance tumor microenvironment regulation and, when paired with disulfiram, effectively kill cancer cells while also showing synergistic anti-tumor effects with immune checkpoint inhibitors.
January 2026 in “Journal of Clinical Case Studies” This article discusses the potential of copper tripeptide (GHK-Cu) to support collagen synthesis and antioxidant activity in the context of androgenetic alopecia but reports no clinical results.
This article reviews the potential benefits of GHK-Cu, EAA, and water-soluble propolis for wound healing, skin tightening, and anti-aging effects, but reports no new clinical results.
May 2026 in “Bioactive Materials” This study reported that in degenerative alopecia, Zn²⁺/Cu²⁺-dependent proteases are downregulated and destabilized, and a specially developed microneedle patch reactivated these enzymes, reduced senescence, and enhanced hair regeneration in an animal model.
This study reports that in a rat model of myocardial infarction, Zn-Cu ion sequential therapy improved cardiac function and cardiomyocyte metabolic activity by precisely regulating ion concentrations and maintaining elevated levels of the Per2 protein, important for cellular repair.
10 citations
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January 2025 in “Biomaterials Science” This study found that a multifunctional hydrogel dressing enriched with Cu-MOF and tannic acid significantly improved full-thickness wound healing in rats, reducing the wound area to only 1.6% and promoting re-epithelialization, neovascularization, and hair follicle formation.
4 citations
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February 2021 in “Zenodo (CERN European Organization for Nuclear Research)” This study measured heavy metal concentrations in Hibiscus rosa-sinensis, Eclipta alba, and Solanum nigrum, finding that levels for Cu, Cr, Cd, Hg, As, and Pb were within WHO safe limits, suggesting these medicinal plant extracts are free from heavy metal toxicity concerns.
22 citations
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November 2010 in “Toxicological & Environmental Chemistry Reviews” In this study, higher concentrations of Pb, Cd, Cu, and Zn were found in the hair of smokers and users of hair dyes compared to non-smokers and those with undyed hair.
12 citations
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June 2022 in “International Journal of Molecular Sciences” In this study, copper was found to promote the proliferation of dermal papilla cells in Rex rabbits by maintaining the function of the cellular mitochondrial electron transport chain.
44 citations
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November 2007 in “Journal of toxicology and environmental health. Part B, Critical reviews” This review explores how copper and zinc concentrations in hair may serve as bioindicators and discusses their potential associations with health disorders, but it reports no new clinical findings.
February 2026 in “Advanced Healthcare Materials” This study proposes a metal-organic gel-encapsulated microneedle system with antibacterial, anti-inflammatory, and pro-angiogenic properties for treating infected wounds, demonstrating potential for precise and adaptive management by targeting various stages of wound healing.
30 citations
,
November 1985 in “American Journal of Veterinary Research” This study observed that cattle grazing all-grass or grass-legume pastures showed varying mineral concentrations in hair, blood, urine, and liver, with significant correlations between hair and serum magnesium and copper levels.
8 citations
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January 2016 This study concluded that replacing the synthetic dye Sunset Yellow with curcumin as a colorant in foods may avoid cytotoxic and genotoxic effects observed in mice.
January 2016 in “Journal of animal research” This study found significant correlations for copper and zinc levels between hair and plasma in Pomeranian and Labrador dogs, but no significant correlation for iron.
March 1963 in “Sangyo Igaku” Women generally have higher levels of iron, copper, and zinc in their hair than men, with differences increasing with age.
52 citations
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October 2010 in “Antiviral Therapy” This review discusses recent advances in monophosphate prodrug strategies for HCV drug discovery, aiming to enhance oral absorption and stability, and reports no new clinical results.