Clinical Snippets

    Lowell A. Goldsmith
    TLDR Razor bumps are linked to a genetic variant, misoprostol helps erythromelalgia pain, steroid ointments don't affect skin rhythms, and certain antibodies are common in localized scleroderma.
    The document discussed several dermatological studies. One study identified a significant association between a single nucleotide polymorphism in the K6hf keratin and pseudofolliculitis barbae (razor bumps), particularly affecting African-American males, with an odds ratio of 6.1. Another study explored erythromelalgia treatment with misoprostol, showing reduced pain and response to body heating. Research on skin circadian rhythms found that steroid ointments did not disrupt these rhythms or skin barrier function. Lastly, antibodies against Cu/Zn superoxide dismutase were found in 89% of localized scleroderma patients, suggesting a potential role in fibrosis and therapeutic implications.
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