Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

Scalp cooling therapy is costly and often not covered by insurance, limiting access for low-income patients.

Genetic factors, especially PADI3 gene variants, contribute to CCCA in women of African descent.

This study reported that Cosmos caudatus extract alone may therapeutically modulate the AR–FGF-2 axis in a BPH rat model, comparable to finasteride, but combining them disrupted pathway regulation, increasing TGF-β levels.

This study found that minicircle-based gene therapy significantly lowered total homocysteine levels and improved liver CBS activity in a mouse model of CBS deficiency.

This review discusses central serous chorioretinopathy, detailing its etiology, associated factors, diagnostic imaging, and therapeutic options, but provides no new clinical findings.

This study found that central centrifugal cicatricial alopecia primarily affects adult women of African descent and suggests an association with traumatic hair care practices and delayed diagnosis.

CCCA may be a fibroproliferative disorder, and anti-fibrotic therapies could help.

This study suggests that the CsA-induced inactivation of the CaN/NFAT pathway may suppress TGF-β2 expression in dermal papilla cells, potentially contributing to CsA-associated hypertrichosis.

This study reported that an HS-associated NCSTN mutation in iPSC-derived skin organoids led to altered hair follicle stem cell differentiation and increased expression of proteins linked to HS inflammation.

This study found that mutations in the PADI3 gene, which is important for hair shaft formation, may contribute to central centrifugal cicatricial alopecia among patients.

In this study, researchers evaluated CS12192, a selective JAK3 inhibitor, in an alopecia areata mouse model and found it reversed hair growth inhibition comparably to baricitinib, with better safety and similar immune-modulating mechanisms.

This study found that in vivo and in vitro, citric acid metabolism through the CS-CA axis suppressed hair growth and induced inflammation and cell apoptosis in hair follicles, suggesting it as a potential therapeutic target.

This study demonstrated that transcutaneous vaccination via cyanoacrylate skin surface stripping effectively induced both CD4 and CD8 T cell responses in humans, offering a promising alternative to intramuscular injection.

This review addresses new therapeutic approaches for complete androgen insensitivity syndrome but reports no new clinical results; the authors emphasize the necessity for multidisciplinary strategies and psychological support in treatment.

CCCA affects Black men too, with a genetic link found in the PADI3 gene.

The authors concluded that VSCAPSI, a videodermoscopy-based assessment tool, provides evidence for early diagnosis, differential diagnosis, follow-up, and screening of scalp psoriasis.

This study evaluated donor area scars in hair restoration using a new assessment scale and found that most patients had good quality scars, with average scores of 15 or less out of 40.

This study observed that a CARASIL mouse model demonstrated abnormal behavior, vascular and cellular changes, and upregulation of the TGF-β/Smad signaling pathway, indicating its potential involvement in CARASIL pathogenesis.

This report presents the first documented case of CARASIL in an Arabic patient and notes unique magnetic resonance spectroscopy findings compared to prior cases.

This study highlights the phenotypic variability in 5 patients with Woodhouse-Sakati syndrome carrying the c.436delC mutation, suggesting a broader range of clinical presentations than previously recognized.

This study found that patients with central centrifugal cicatricial alopecia were less likely to report treatment improvement and more commonly associated with certain hairstyling practices compared to those with other scarring alopecias.

This study reports two cases of central serous chorioretinopathy developing after intralesional corticosteroid injections to the scalp for alopecia areata, suggesting a potential association that warrants cautious use and monitoring for ocular complications.

Hair shaft malformation contributes to Central Centrifugal Cicatricial Alopecia.

In liver cancer cells, this study found that upregulating hsa_circ_0002980 inhibits cell proliferation, metastasis, and EMT by modulating the miR-1303/CADM2 axis, suggesting it as a potential therapeutic target.

This article reports three cases of African American men with central centrifugal cicatricial alopecia, highlighting the need to consider this diagnosis for male patients with vertex hair loss and scalp symptoms.

This study found that the cytochrome P450 enzyme CYP-sb21 can hydroxylate cyclosporine A at multiple positions, reducing its immunosuppressive effects but retaining its hair growth-promoting side-effect, and suggests modifications to improve regioselectivity for commercial use.

This research introduces WomenCare, a web-based system using a machine learning model to predict PCOD risk by evaluating factors like age, BMI, and lifestyle habits; it aims to help women monitor their health but is not a substitute for a professional diagnosis.

This study suggests that patients with severe, extensive central centrifugal cicatricial alopecia may exhibit a distinct gene expression pattern in the lesional scalp, highlighting potential targets for future research on disease severity and therapies.

This submission critiques policies on "effective referral" for euthanasia and assisted suicide, highlighting potential threats to physicians' civil liberties and suggesting revisions to uphold freedom of conscience in medical practice.

This study found that SPARC-overexpressing adipose-derived mesenchymal stem cells significantly improved various aspects of skin wound healing in dogs, including re-epithelialization, collagen deposition, and angiogenesis, showing promise for enhancing treatment effectiveness under different physiological and pathological conditions.