Using Scanning Electron Microscopy to Elucidate the Role of Hair Shaft Malformation in the Pathogenesis of Central Centrifugal Cicatricial Alopecia

June 2020 in “ Journal of Investigative Dermatology ”

Erinolaoluwa F. Araoye, Ncoza C. Dlova, Crystal Aguh

Central Centrifugal Cicatricial Alopecia scarring alopecia hair shaft malformation PID3 gene uncombable hair syndrome scanning electron microscopy SEM ImageJ software

TLDR Hair shaft malformation contributes to Central Centrifugal Cicatricial Alopecia.

The study investigated the role of hair shaft malformation in Central Centrifugal Cicatricial Alopecia (CCCA), a scarring alopecia prevalent in black women, by examining hair samples under scanning electron microscopy (SEM). It focused on the genetic basis of CCCA, particularly the PID3 gene, which is linked to hair shaft formation and uncombable hair syndrome. Hair samples from CCCA patients and controls were analyzed for cross-sectional shape, area, aspect ratio, and circularity using ImageJ software. The findings aimed to clarify how hair shaft differences contribute to CCCA's pathogenesis.

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34 citations , August 2003 in “Clinical and Experimental Dermatology”

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