Using Scanning Electron Microscopy to Elucidate the Role of Hair Shaft Malformation in the Pathogenesis of Central Centrifugal Cicatricial Alopecia

    June 2020 in “ Journal of Investigative Dermatology ”
    Erinolaoluwa F. Araoye, Ncoza C. Dlova, Crystal Aguh
    TLDR Hair shaft malformation contributes to Central Centrifugal Cicatricial Alopecia.
    The study investigated the role of hair shaft malformation in Central Centrifugal Cicatricial Alopecia (CCCA), a scarring alopecia prevalent in black women, by examining hair samples under scanning electron microscopy (SEM). It focused on the genetic basis of CCCA, particularly the PID3 gene, which is linked to hair shaft formation and uncombable hair syndrome. Hair samples from CCCA patients and controls were analyzed for cross-sectional shape, area, aspect ratio, and circularity using ImageJ software. The findings aimed to clarify how hair shaft differences contribute to CCCA's pathogenesis.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 3 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

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