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The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The Rotterdam Study aims to understand various diseases in older adults.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.

Muscles and nerves that cause goosebumps also help control hair growth.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

Thyroid hormone affects skin health, with too little causing rough, pale skin and too much leading to smooth, thin skin, and may also impact wound healing and skin conditions.

Special immune cells called Regulatory T cells help control skin inflammation and repair in various skin diseases.

Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

Quercitrin may help treat hair loss by promoting hair growth and improving cell health.

Thyroid hormones affect skin texture, hair and nail growth, and can cause skin diseases related to thyroid problems.

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

Stem cell differentiation is crucial for skin barrier maintenance and its disruption can lead to skin diseases.

Researchers identified specific genes that are important for mouse skin cell development and healing.

Whale genes show changes that help them live in water, like less hair and better flippers.