102 citations
,
October 2010 in “Molecular Pharmaceutics” In this study, copper-doxorubicin liposomes with multidose therapy reduced systemic toxicity compared to ammonium sulfate-loaded doxorubicin liposomes, while combinatorial strategies further enhanced tumor regression and accumulation.
June 2025 in “Journal of Cluster Science” This review explores the potential of metal nanoparticles as innovative treatments for alopecia, highlighting their effectiveness in promoting hair regrowth, enhancing drug delivery, and modulating gene expression while also assessing the related experimental methodologies and regulatory considerations.
7 citations
,
August 2020 in “Plastic and reconstructive surgery. Global open” In this study, QR 678 and QR 678 Neo formulations containing growth factors and peptides were found to be safe in vitro and promoted hair growth in vivo in an animal model, suggesting their potential as treatments for alopecia, including secondary alopecia post-chemotherapy.
114 citations
,
October 2009 in “Gastroenterology” This review discusses zinc's role as an essential trace element in human nutrition, particularly its importance in total parenteral nutrition, and reports no new clinical results.
4 citations
,
May 2022 in “Journal of Drug Delivery Science and Technology” This research observed that nanoliposomes delivering a combination of bioactive peptides significantly promoted hair growth in vitro and in vivo by enhancing the proliferation and function of hair growth-targeted cells in C57BL/6 mice, suggesting a promising approach for treating androgenetic alopecia.
50 citations
,
February 2022 in “Nanomaterials” This review discusses the mechanisms involved in wound healing and explores the potential of nanomaterials as a promising approach to managing chronic wounds, but reports no new clinical findings.
23 citations
,
November 1964 in “Journal of Dairy Science” This study found that high molybdenum levels in the diet, especially with added sulfate sulfur, led to symptoms like alopecia and hair color loss in heifers; however, these were corrected by adding copper.
September 2020 in “Nature, Environment and Pollution Technology/Nature, environment and pollution technology” This study found that Wistar rats fed with grass extracts from mining areas accumulated trace metals, particularly in the spleen, leading to organ pathology and signs of toxicity.
6 citations
,
September 1957 in “Poultry Science” This study found that adding molybdenum to poultry diets depressed growth without affecting feather pigmentation, and copper supplementation tended to counteract the growth inhibition.
25 citations
,
January 1992 in “International Journal of PIXE” This review discusses medical conditions and therapies related to various elements, such as zinc, copper, mercury, cadmium, lead, chromium, and arsenic, without reporting new experimental results; it highlights past findings on deficiencies, toxicities, and historical cases.
24 citations
,
June 2010 in “Clinics in Dermatology” This review discusses various potential adverse effects of common oral vitamin and mineral supplements used in dermatology and highlights lesser-known issues like hematologic and neurologic effects from zinc.
66 citations
,
November 1997 in “Nutrition” This study found that while micronutrient abnormalities are common among patients receiving home parenteral nutrition, serious consequences from these abnormalities are rare.
May 2023 in “Materials research foundations” The researchers highlighted that using nanomaterials for wound care could significantly improve healing by delivering antibacterial, antifungal, and anti-inflammatory effects, and may potentially reduce the economic burden associated with wound treatment.
165 citations
,
January 2008 in “Journal of biomaterials science. Polymer ed.” This review outlines the various processes activated by the peptide GHK-Cu in tissue remodeling and reports improvements in skin and wound healing but notes a need for further study to fully understand these mechanisms.
4 citations
,
March 2006 in “Journal of renal nutrition” This study found that hemodialysis patients taking water-soluble vitamins had a 16% lower mortality risk compared to those not taking any, but the specific supplementation needed remains unclear.
8 citations
,
November 2023 in “Frontiers in Bioengineering and Biotechnology” This article reviews recent developments in microneedles combining metallic elements and herbal compounds for wound healing, highlighting their benefits such as enhanced therapeutic efficacy and reduced toxicity, and offering a reference for future advancements in this technology.
36 citations
,
September 2019 in “Journal of Herbal Medicine” This review explores research on nanoformulations for enhancing the topical delivery of herbal medicines, noting potential benefits like improved bioavailability and sustained delivery, and emphasizes the need for safety and toxicity guidelines in developing these novel drug delivery systems.
55 citations
,
September 2020 in “Frontiers in Bioengineering and Biotechnology” This review discusses surface engineered metal-organic frameworks for wound healing and reports no new clinical results; it highlights their potential as antibacterial agents, therapeutic delivery systems, and wound dressings.
24 citations
,
November 2023 in “Regenerative Biomaterials” In this review, the authors summarized the potential therapeutic effects of metal ions in treating cardiovascular diseases, highlighting their roles in protecting cells, inducing angiogenesis, and adjusting ion channel functions, as well as discussing delivery strategies involving biomaterials.
June 2023 in “Research Square (Research Square)” This study demonstrated that dietary cupric citrate improved growth performance and nutrient utilization in broilers, while also altering their intestinal microbiota and increasing the pH in the duodenum and jejunum.
78 citations
,
December 2011 in “Clinical toxicology” This study describes a case series of nine patients experiencing symptoms of selenium toxicity after consuming a liquid dietary supplement with an excess amount of selenium.
This book chapter discusses the mechanisms and prevention of selenium toxicity in livestock and reports no new experimental results; it emphasizes reducing selenium in the human food chain through animal products.
3 citations
,
February 2016 in “Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Māzandarān/Journal of Mazandaran University of Medical Sciences” This study observed that noncertified Kohl used in Iranian cities contained heavy metals within WHO suggested limits, but highlighted concerns due to high levels in some samples.
April 1981 in “Pediatric research” This study found that abnormal liver and kidney copper metabolism in Br females had no clinical effects, whereas defective brain copper metabolism in Br males was clinically significant.
July 2020 in “Environmental Science and Pollution Research” This study found that finasteride and melengestrol acetate exhibit varying levels of toxicity to freshwater mussels, amphipods, and mayflies, but current environmental concentrations suggest minimal direct effects on these aquatic invertebrates.
103 citations
,
January 2009 in “Carbon” This study found that carbon nanotube impurities induced immunological toxicity in mice, whereas purified nanotubes showed good biocompatibility, suggesting high-temperature thermal treatment may improve nanotube biocompatibility.
19 citations
,
March 2011 in “Cutaneous and Ocular Toxicology” Some chemicals absorbed through the skin can cause serious health problems.
42 citations
,
April 2012 in “Seminars in Oncology” This review discusses the skin side effects associated with targeted cancer therapies and reports no new clinical results; it emphasizes the need for empirical management based on expert opinion.
16 citations
,
March 2007 in “The Veterinary clinics of North America. Food animal practice” This article discusses misconceptions around mineral nutrition in beef cattle and emphasizes that sub-clinical deficiencies or toxicities, rather than overt symptoms, often cause economic losses, but it reports no new findings.
2 citations
,
April 2025 in “Biomedicine & Pharmacotherapy” This research reports that copper-quercetin complexes show strong potential in antioxidation and cancer therapy, while their effects on specific cell death pathways warrant further investigation.