1 citations
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February 2022 in “Open Access Macedonian Journal of Medical Sciences” This study found that lower zinc serum levels may contribute to premature hair graying in college students at Universitas Sumatera Utara.
1 citations
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January 2016 in “American Journal of Clinical and Experimental Medicine” This study found that men with androgenic alopecia had significantly different hair copper levels compared to controls, but no difference in blood copper levels between the groups was observed.
37 citations
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March 2014 in “Journal of Trace Elements in Medicine and Biology” This study reported that Turkish males with male pattern androgenetic alopecia had significantly lower zinc and copper levels in their hair compared to healthy controls, suggesting these imbalances may play a role in the condition's etiology.
In this study, a copper-deficient diet in rats led to a significant decrease in blood and liver copper levels without causing clinical symptoms, while hair leachable copper and bone copper remained unchanged.
3 citations
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June 2019 in “Journal of Bangladesh Society of Physiologist” This study found that patients experiencing hair loss had significantly lower serum levels of zinc and copper compared to healthy controls.
January 2026 in “International Journal of Pharmaceutical Quality Assurance” In this study, researchers observed that patients with Alopecia Areata had significantly lower serum zinc and higher copper levels compared to healthy controls, indicating a disrupted zinc-copper balance that may contribute to the disease's pathogenesis.
January 2004 in “Trace Elements Science” This study observed that hair levels of chromium, manganese, and copper were lower in diabetics compared to controls, while iron levels were higher.
September 2024 in “African Journal of Biomedical Research” This study found that individuals with alopecia areata had significantly lower blood levels of vitamin D and slightly lower serum copper levels compared to healthy controls, suggesting the potential importance of assessing these factors in the chemical evaluation of patients with this condition.
March 2024 in “BMC women's health” This study found that free testosterone levels were 29% higher with the levonorgestrel implant than with the DMPA injection, which may impact sexual function, mood, and side effects like acne.
2 citations
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January 1977 in “PubMed” 1 citations
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January 1985 in “IRIS UNIMORE (University of Modena and Reggio Emilia)” 7 citations
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December 2017 in “Basrah Journal of veterinary Research” This study in Basra province sheep reported that zinc and copper deficiencies were linked to various clinical signs and affected oxidative stress and antioxidant levels.
August 2024 in “Journal of Cosmetic Dermatology” This study investigates differences in nutritional status, vitamin, and mineral levels between individuals with telogen effluvium and a control group, aiming to understand the nutritional factors involved in this condition.
9 citations
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January 2013 This study found that serum levels of zinc, copper, and selenium were significantly lower in patients with alopecia areata compared to healthy controls, regardless of the number of hair loss patches.
1 citations
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November 2011 in “Dermatologica Sinica” This study found a significant decline in serum zinc levels among women of African descent using hair relaxers and experiencing alopecia, with age at first exposure potentially influencing alopecia development.
January 2013 in “Food science and technology research” This study reported that green tea extract may promote the excretion of copper into the hair in mice.
April 2023 in “Acta Poloniae Pharmaceutica” This study found that using Urtica cannabina extract shampoo led to increased levels of copper, zinc, and iodine in the scalp hair of Mongolian women, along with improvements in hair growth, diameter, and density compared to a regular shampoo.
July 2018 in “Journal of College of Medical Sciences-nepal” This study found a significant association between lower serum ferritin levels and chronic diffuse hair loss in women of reproductive age, particularly in cases of alopecia areata and androgenetic alopecia.
25 citations
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June 1998 in “Biological Trace Element Research” This study found that young healthy women with a family history of noninsulin-dependent diabetes mellitus exhibited higher zinc and lower copper concentrations in hair compared to those without such a family history, suggesting a possible Cu-Zn antagonism.
June 2024 in “Research Square (Research Square)” This study found that women experiencing hair loss post-COVID-19 showed significantly decreased serum copper levels, suggesting potential further research into copper supplementation for preventing and treating post-COVID-19 alopecia.
May 2024 in “Pakistan Journal of Health Sciences” This study found that people with chronic telogen effluvium had lower hair and serum iron levels and higher serum copper levels compared to healthy controls.
December 2021 in “Dermatology research” This study found that individuals with premature graying of hair had significantly lower serum levels of vitamin B12, ferritin, and calcium compared to those without premature graying.
February 2021 in “INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH” This study found that women with telogen effluvium had significantly lower serum copper and zinc levels compared to controls, suggesting these deficiencies may be associated with the condition.
6 citations
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January 2018 in “PubMed” This study suggests that elevated levels of certain heavy metals, rather than zinc, may play a causative role in primary chronic telogen effluvium.
January 2022 in “Indian journal of paediatric dermatology” In this study, patients with premature graying of hair had lower levels of zinc, magnesium, and Vitamin B12 compared to healthy controls.
February 2019 in “Trace elements and electrolytes” This study found that women with chronic telogen effluvium had significantly lower levels of zinc, copper, and ferritin in their serum compared to healthy controls.
23 citations
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February 2017 in “Journal of dermatology” This meta-analysis suggests that patients with alopecia areata have lower serum levels of zinc and selenium compared to healthy controls, which may be important risk factors for the condition.
November 2025 in “Biological Trace Element Research” This pilot study found no significant relationship between blood and hair mineral concentrations in generally healthy adults, though hair analysis may have potential for assessing long-term mineral trends.
July 2019 in “International journal of dermatology, venereology and leprosy sciences” This study found that patients with Telogen effluvium had significantly higher levels of heavy metals, such as cadmium and lead, compared to controls.
16 citations
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October 2015 in “Photochemistry and photobiology” This study found that higher concentrations of copper (II) ions in human hair increase protein oxidative modification, contributing to hair damage regardless of UV exposure and pigmentation level.