21 citations
,
January 2014 in “Dermatology Research and Practice” This study found no significant difference in serum and hair levels of iron, zinc, and copper between female alopecia areata patients and healthy controls.
2 citations
,
October 2018 in “The journal of pediatrics/The Journal of pediatrics” This case report identified a 4-month-old boy with Menkes disease, a neurodegenerative disorder of copper metabolism, noting symptoms like recurrent seizures, developmental delay, and specific physical characteristics, confirmed by genetic sequencing showing a pathogenic ATP7A mutation and low serum copper and ceruloplasmin levels.
June 2025 in “Clinical Cosmetic and Investigational Dermatology” This study examined the factors contributing to gray hair, such as genetics and lifestyle, and found that while graying correlates with some health conditions, it is primarily a physiological process rather than a pathological one.
17 citations
,
January 2018 in “International Journal of Trichology” This study found that patients with premature hair graying had lower serum levels of iron, copper, and calcium, which correlated with the severity of graying.
July 2026 in “Frontiers in Veterinary Science” This study found that combined dietary supplementation of sodium hyaluronate and eggshell membrane was associated with various improvements in skin and coat health markers in healthy Ragdoll cats.
August 2023 in “Journal of The American Academy of Dermatology” In this commentary, the authors highlighted that valproic acid, unlike lamotrigine, is notably associated with alopecia in various studies, with an incidence rate up to 12% and mechanisms involving telogen effluvium and hyperandrogenism contributing to hair loss in patients.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This source provides supplementary materials for the Carnivore Follicular Integrity Framework, a theoretical model proposing that animal-based diets may support hair follicle stability through several biological mechanisms. The materials include definitions, nutrient tables, and mechanistic notes but do not report empirical results.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This record provides supplementary materials for a theoretical model suggesting that animal-based diets may support hair follicle stability through various biological mechanisms, including regenerative peptides and anti-glycation protection.
73 citations
,
May 1976 in “JAMA” This case report associates severe zinc deficiency with long-term total parenteral nutrition, suggesting the need for trace element supplementation in such nutritional management.
10 citations
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May 1986 in “Experientia” This animal study found that second generation mice exposed to excess zinc during gestation and lactation had reduced plasma copper, body weight, and hematocrit, with lighter and delayed hair development compared to mice on a normal zinc diet.
114 citations
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October 2009 in “Gastroenterology” This review discusses zinc's role as an essential trace element in human nutrition, particularly its importance in total parenteral nutrition, and reports no new clinical results.
4 citations
,
January 2020 in “Skin appendage disorders” This study highlighted that toxic metals, particularly thallium, arsenic, selenium, and mercury, are commonly associated with cases of alopecia areata.
December 2009 in “DergiPark (Istanbul University)” This study found that low levels of ferritin and iron were common among women with diffuse hair loss, suggesting these tests could be useful in evaluating such patients.
6 citations
,
February 1998 in “PubMed” This study found that patients with MPA had significantly lower zinc and manganese levels and higher copper levels in their hair compared to hair-healthy men.
March 2024 in “International journal of molecular sciences” This study suggests that abnormal levels of zinc, copper, and iron in serum or hair may serve as auxiliary and prognostic tests for various skin diseases, though further research is necessary due to conflicting data.
3 citations
,
February 2016 in “Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Māzandarān/Journal of Mazandaran University of Medical Sciences” This study observed that noncertified Kohl used in Iranian cities contained heavy metals within WHO suggested limits, but highlighted concerns due to high levels in some samples.
March 1963 in “Sangyo Igaku” Women generally have higher levels of iron, copper, and zinc in their hair than men, with differences increasing with age.
23 citations
,
November 1964 in “Journal of Dairy Science” This study found that high molybdenum levels in the diet, especially with added sulfate sulfur, led to symptoms like alopecia and hair color loss in heifers; however, these were corrected by adding copper.
10 citations
,
January 1980 in “Ultrastructural pathology” This study suggests that elevated copper levels in domestic tapwater, exacerbated by its aggressive properties, likely contribute to green hair by damaging the cuticle and increasing copper uptake.
June 2024 in “Journal of Islamic International Medical College” This study evaluated serum copper and zinc levels in individuals with various types of alopecia and found that low zinc levels are associated with all types of alopecia, while low copper levels are specifically related to male pattern hair loss.
December 2023 in “Archives of iranian medicine” This study used hair samples to assess mineral levels and found that higher iron status may be associated with an increased risk of esophageal squamous cell carcinoma, while no significant associations were observed for copper and magnesium levels in this cohort.
26 citations
,
October 2011 in “Biological trace element research” This study observed that lower serum copper levels may be linked to premature hair graying in young patients compared to controls.
January 2004 in “Weiliang yuansu yu jiankang yanjiu” This study found that copper levels varied significantly by gender, while young infants had higher levels of copper, zinc, calcium, magnesium, and iron compared to older age groups.
4 citations
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October 2011 in “Medical journal of Tabriz University of Medical Sciences and Health Services” This study suggests that lower levels of zinc and copper in hair and serum, along with altered oxidative stress markers, may contribute to the development of alopecia areata and androgenetic alopecia.
4 citations
,
June 1980 in “American Journal of Clinical Nutrition” Malnutrition can change hair color due to altered copper and zinc levels.
73 citations
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January 2013 in “Annals of Dermatology” This study observed that patients with various types of hair loss had significantly lower serum zinc levels compared to healthy controls, suggesting zinc disturbance may play a role in the condition.
October 2014 in “Journal of Nutrition & Food Sciences” This study found that in visceral-obese Korean adults, hair chromium and selenium levels were inversely associated with insulin resistance, while copper levels showed a positive association.
January 1992 in “Journal of Oriental Neuropsychiatry” This study found that zinc, copper, and chromium levels were significantly lower in the hair of Korean individuals with schizophrenia compared to healthy individuals.
May 2014 in “The Journal of Alternative and Complementary Medicine” Higher levels of chromium, selenium, and copper in hair are linked to increased insulin resistance in visceral-obese adults.
January 2025 in “Open Veterinary Journal” This study found that sheep with deficiencies in zinc, copper, and vitamin A exhibited symptoms like weight loss, skin disorders, and abnormal hematological and antioxidant enzyme levels compared to healthy sheep, suggesting that dietary supplementation of these nutrients could prevent these health issues.