114 citations
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October 2009 in “Gastroenterology” This review discusses zinc's role as an essential trace element in human nutrition, particularly its importance in total parenteral nutrition, and reports no new clinical results.
63 citations
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May 2017 in “American Journal of Clinical Dermatology” This review found that patients with alopecia areata may have lower levels of vitamin D, zinc, and folate, but conflicting evidence precludes definitive clinical recommendations for micronutrient supplementation.
9 citations
,
January 2013 This study found that serum levels of zinc, copper, and selenium were significantly lower in patients with alopecia areata compared to healthy controls, regardless of the number of hair loss patches.
July 1998 in “Hair transplant forum international” This article discusses the need to focus on improving telogen effluvium and healing speed in hair transplantation but reports no new research findings.
February 2025 in “JAAD International” Five monthly sessions of minoxidil-dutasteride-copper peptide tattooing significantly improve hair regrowth in men with androgenetic alopecia.
15 citations
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January 2016 in “Przeglad Menopauzalny” This review discusses the role of diet in managing hair loss during menopause and reports no new clinical results; it highlights the importance of nutrients like sulfur amino acids, vitamins, and minerals.
1 citations
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December 2015 in “Lʹvìvsʹkij klìnìčnij vìsnik” This review discusses the connection between alopecia areata and trace element imbalances, noting deficiencies in elements like zinc and selenium, but reports no new clinical findings.
This review discusses the role of nutrients in hair graying management and finds a possible link between low copper, iron, and vitamin B12 levels and premature hair graying.
July 2018 in “International journal of clinical & experimental dermatology” This narrative review describes the components of human hair and their nutritional importance but reports no clinical results; the authors suggest dietary sulfur amino acids are essential for hair health.
October 2017 in “The American journal of gastroenterology” This case series highlights severe micronutrient deficiencies and complications in three patients who did not adhere to follow-up care after Roux-en-Y gastric bypass, emphasizing the importance of regular nutritional monitoring.
June 2006 in “Almustansiriya journal of pharmaceutical sciences/Al-Mustansiriyah journal of pharmaceutical sciences” This study found that melatonin may reduce the dose of prednisone needed for treating alopecia areata and its associated side effects by attenuating free radical damage on the immune system.
January 2026 in “Journal of Clinical Case Studies” This article discusses the potential of copper tripeptide (GHK-Cu) to support collagen synthesis and antioxidant activity in the context of androgenetic alopecia but reports no clinical results.
198 citations
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October 1986 in “Differentiation” 74 citations
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July 1995 in “PubMed” This study suggests that reversible hypopigmentation in homocystinuric patients may result from tyrosinase inhibition by homocyst(e)ine, with in-vitro experiments showing copper sulfate reversing this inhibition.
October 2024 in “Journal of the Pakistan Medical Association” This letter discusses the various risk factors associated with premature greying of hair, highlighting genetic predispositions, nutritional deficiencies, stress, and lifestyle factors, while noting a lack of conclusive data on effective interventions, as detailed in the reviewed studies.
October 2014 in “Journal of Nutrition & Food Sciences” This study found that in visceral-obese Korean adults, hair chromium and selenium levels were inversely associated with insulin resistance, while copper levels showed a positive association.
24 citations
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June 2010 in “Clinics in Dermatology” This review discusses various potential adverse effects of common oral vitamin and mineral supplements used in dermatology and highlights lesser-known issues like hematologic and neurologic effects from zinc.
14 citations
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April 2000 in “Animal Science/Animal science” This article explores how various nutrients and metabolic processes impact wool and hair follicle function in animals but reports no new experimental findings.
1 citations
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December 2022 in “Bioactive Materials” In this study, researchers developed a nanocomposite microneedle patch containing copper/zinc dual-doped silica nanoparticles, which release substances to promote hair follicle regeneration by targeting various pathophysiological aspects of androgenic alopecia, presenting an effective anti-hair loss treatment strategy.
July 2011 in “Springer eBooks” This review discusses both conventional and new pharmaceutical treatments for hair loss, as well as various natural and herbal remedies, but reports no new clinical results.
21 citations
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January 2014 in “Dermatology Research and Practice” This study found no significant difference in serum and hair levels of iron, zinc, and copper between female alopecia areata patients and healthy controls.
18 citations
,
December 2010 in “Journal of Trace Elements in Medicine and Biology” This study suggests that alterations in copper metabolism may play a key role in the development of androgenetic alopecia in women, presenting potential targets for treatment strategies.
16 citations
,
October 2015 in “Photochemistry and photobiology” This study found that higher concentrations of copper (II) ions in human hair increase protein oxidative modification, contributing to hair damage regardless of UV exposure and pigmentation level.
15 citations
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July 2012 in “Biological trace element research” This study found that an increased calcium/magnesium ratio in hair and lower chromium concentration were associated with higher insulin resistance in Korean adult males.
12 citations
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January 2014 in “Cell structure and function” This study suggests that specific combinations of human type I and II hair keratins, particularly K35-K85 and K36-K81, have distinct in vitro assembly properties that are significant for macrofibril formation.
5 citations
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January 2022 in “Pesquisa Veterinária Brasileira” The study described an outbreak of copper deficiency in dairy goats and kids in Pernambuco, Brazil, leading to various clinical and reproductive issues in the animals, including enzootic ataxia in kids.
4 citations
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March 2006 in “Journal of renal nutrition” This study found that hemodialysis patients taking water-soluble vitamins had a 16% lower mortality risk compared to those not taking any, but the specific supplementation needed remains unclear.
3 citations
,
November 2020 in “Biological Trace Element Research” This study found that patients with androgenetic alopecia had deficiencies in certain trace elements and vitamins, which were linked to distinct patterns of hair loss connected to androgen levels.
1 citations
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June 2007 in “Almustansiriya journal of pharmaceutical sciences/Al-Mustansiriyah journal of pharmaceutical sciences” This study found that a two-month antioxidant treatment significantly improved hair growth in patients with alopecia areata by enhancing antioxidant defenses and correcting trace metal imbalances.
November 2025 in “Biological Trace Element Research” This pilot study found no significant relationship between blood and hair mineral concentrations in generally healthy adults, though hair analysis may have potential for assessing long-term mineral trends.