11 citations,
September 2021 in “Journal of molecular endocrinology” ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.
11 citations,
May 2009 in “Medical Hypotheses” Male pattern baldness is an unintended side effect of the body's use of androgens for muscle growth, especially in those genetically prone to it.
11 citations,
January 1985 in “Archives of Dermatology” Topical antiandrogens might treat skin issues like hair growth, balding, and acne, but finding effective treatments without side effects is challenging.
11 citations,
November 1982 in “British journal of dermatology/British journal of dermatology, Supplement” Testosterone and some of its forms can strongly stimulate oil gland growth in skin.
11 citations,
February 1980 in “BMJ. British medical journal” Hirsutism is common body hair growth due to genetics and hormones, and while not a disease, it can be distressing; virilisation includes hirsutism with other male traits and needs medical attention.
11 citations,
January 1980 in “Southern Medical Journal” Minoxidil effectively treats severe hypertension but has notable side effects.
10 citations,
August 2020 in “International Journal of Andrology” 5α-reductase inhibitors like finasteride may not be effective or safe for transgender individuals, and more research is needed.
10 citations,
January 2019 in “in Vivo” Finasteride boosts stem cell signals for hair growth.
10 citations,
October 2018 in “Sexual medicine reviews” Men using hair loss drugs like finasteride may experience sexual side effects like erectile dysfunction, but it's unclear who will be affected and when. Treating depression and sexual symptoms is suggested, as these men often have higher rates of both. More research is needed to understand why these side effects occur.
10 citations,
January 2018 in “Elsevier eBooks” Burn scars heal abnormally and more research is needed to find better treatments.
10 citations,
December 2015 in “International Journal of Molecular Sciences” PDCD4 is important for controlling skin cell growth and healing.
10 citations,
June 2014 in “Journal of Pharmacy and Pharmacology” Germacrone in Curcuma aeruginosa extract degrades at high temperatures but is stable in certain solutions and unaffected by pH levels.
10 citations,
February 2011 in “Journal der Deutschen Dermatologischen Gesellschaft” The document concludes that proper diagnosis and evidence-based treatments are crucial for managing hair diseases, and psychological support for patients is important.
10 citations,
November 2010 in “Journal of Dermatology” Longer CAG repeats in gene linked to more severe hair loss in females.
10 citations,
June 2010 in “Expert Opinion on Drug Metabolism & Toxicology” Finasteride reduces prostate cancer risk but may increase high-grade cancer chances.
10 citations,
October 2008 in “Andrologia” Finasteride changes antioxidant enzyme expression, possibly affecting sperm protection in rats.
10 citations,
February 2008 in “Photochemistry and photobiology” Vitamin D receptor can control the hairless gene linked to hair loss even without vitamin D.
10 citations,
March 2007 in “Dermatology” Sex-determining genes may affect male baldness.
9 citations,
January 2018 in “American Journal of Men's Health” Finasteride use can cause lasting negative effects like sexual dysfunction, depression, anxiety, and cognitive issues.
9 citations,
October 2012 in “Frontiers of Hormone Research” Antiandrogens are the main treatment for hirsutism, with individualized care and safe, affordable options needed.
9 citations,
March 2009 in “European Journal of Dermatology” Schisandra nigra extract may help hair grow by stimulating cells and preventing hair follicle damage.
9 citations,
November 2003 in “Journal of Investigative Dermatology” Low serum ferritin levels are linked to hair loss in women.
9 citations,
October 1993 in “The Journal of Clinical Pharmacology” Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.
8 citations,
June 2020 in “The Journal of Clinical Endocrinology and Metabolism” Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.
8 citations,
June 2020 in “International Journal of Dermatology” Men with early hair loss have lower vitamin D levels.
8 citations,
October 2018 in “Dermatologic Therapy” About 41% of Indian hair loss patients have low enzyme activity that affects hair loss treatment effectiveness, with men affected more than women. Testing for this can guide treatment.
8 citations,
December 2016 in “Revista Medica De Chile” Finasteride can cause sexual dysfunction, sperm changes, and affect bone density and metabolism.
8 citations,
January 2016 in “Evidence-based Complementary and Alternative Medicine” Rumex japonicus extract may promote hair growth more effectively than Minoxidil.
8 citations,
July 2014 in “General and Comparative Endocrinology” Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.
8 citations,
August 2011 in “Journal of Pharmacology and Experimental Therapeutics” Dosing time affects finasteride's effectiveness and safety in rats.