research Melatonin Protects Cochlear Hair Cells from Nicotine-Induced Injury Through Inhibiting Apoptosis, Inflammation, Oxidative Stress, and Endoplasmic Reticulum Stress
Melatonin may protect ear cells from damage caused by nicotine.
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research Deferoxamine Protects Cochlear Hair Cells Against Tert-Butyl Hydroperoxide-Induced Ototoxicity
Deferoxamine may help protect inner ear cells from damage caused by oxidative stress.
research Whole Neonatal Cochlear Explants as an In Vitro Model
The new method makes it easier to study the whole cochlea from newborn mice and rats in the lab.
research The Structural and Functional Aspects of Hair Cell Regeneration in the Chick as a Result of Exposure to Intense Sound
Chickens exposed to loud noise can quickly regain hearing mostly due to repair of the tectorial membrane, not just hair cell regeneration.
research Follistatin Promotes LIN28B-Mediated Supporting Cell Reprogramming and Hair Cell Regeneration in the Murine Cochlea
Follistatin and LIN28B together improve the ability of inner ear cells in mice to regenerate into hearing cells.
research Caffeine Induces Autophagy and Apoptosis in Auditory Hair Cells via the SGK1/HIF-1α Pathway
Caffeine can damage hearing cells and affect hearing recovery after ear trauma.
research Estradiol Protects Hair Cells From Cisplatin-Induced Ototoxicity Via Nrf2 Activation
Estradiol may protect ear cells from hearing loss caused by a chemotherapy drug by activating a protective pathway.
research 4-Octyl Itaconate Alleviates Cisplatin-Induced Ferroptosis Possibly Via Activating the NRF2/HO-1 Signalling Pathway
4-octyl itaconate may prevent hearing loss caused by the drug cisplatin by activating certain cell protection pathways.
research Inhibition of CISD1 Attenuates Cisplatin-Induced Hearing Loss in Mice via the PI3K and MAPK Pathways
Blocking CISD1 reduces hearing loss from cisplatin in mice.
research CaBP1 and 2 Enable Sustained CaV1.3 Calcium Currents and Synaptic Transmission in Inner Hair Cells
CaBP1 and CaBP2 are important for maintaining hearing by supporting continuous calcium currents and nerve signaling in the ear.
research CaBP1 and 2 Enable Sustained CaV1.3 Calcium Currents and Synaptic Transmission in Inner Hair Cells
CaBP1 and CaBP2 are important for continuous hearing by preventing inactivation of calcium currents in ear cells, with CaBP2 also able to restore hearing when reintroduced.
research A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2+ Progenitors in Neonatal Mouse Inner Ear Organoids
A low dose of rapamycin increases inner ear hair cell creation by boosting SOX2+ cell numbers.
research CaBP1 and 2 Enable Sustained CaV1.3 Calcium Currents and Synaptic Transmission in Inner Hair Cells
CaBP1 and 2 are necessary for maintaining calcium currents and hearing in inner ear cells.
research Molecular Basis of Hair Cell Loss
The document concludes that there are no effective clinical treatments for hearing loss due to hair cell damage, but research is ongoing.
research Ototoxicity of Common Topical Antimycotic Preparations
Clotrimazole, miconazole, and tolnaftate are likely safe, but gentian violet is risky.
research Rapamycin But Not Acarbose Decreases Age-Related Loss of Outer Hair Cells in the Mouse Cochlea
Rapamycin reduces age-related hearing cell loss in mice, but acarbose does not.
research Autophagy-Related Protein 12 Associates With Anti-Apoptotic B Cell Lymphoma-2 to Promote Apoptosis in Gentamicin-Induced Inner Ear Hair Cell Loss
Blocking autophagy increases survival of inner ear hair cells exposed to gentamicin.
research A Counter Gradient of Activin A and Follistatin Instructs the Timing of Hair Cell Differentiation in the Murine Cochlea
Activin A speeds up ear hair cell differentiation, while Follistatin slows it down.
research Minoxidil Dose Response Study in Female Pattern Hair Loss Patients Determined to Be Non-Responders to 5% Topical Minoxidil
Higher minoxidil dose helps hair growth in non-responders without side effects.
research From Genotoxic Stresses to Skin Damage: Distinct, Novel Mechanisms of Skin and Hair Damage in Chemo/Radiation Therapy
Chemotherapy and radiation therapy cause skin and hair damage by altering gene expression and signaling pathways.
research Early and Late Matrix Progenitors Form the Terminally Differentiated Cell Layers of the Hair Follicle
Early and late matrix progenitors in hair follicles create different cell layers, with early ones forming the companion layer and later ones forming the inner root sheath and hair shaft.
research Spatiotemporal Antagonism in Mesenchymal-Epithelial Signaling in Sweat Versus Hair Fate Decision
Sweat glands and hair follicles are determined by opposing signals, with BMPs promoting sweat glands and blocking BMPs leading to hair follicles.
research Applying FACS-Based Single Cell RNA-Seq to Study Neonatal Mouse Skin
Researchers improved a method to study individual cells in newborn mouse skin and found a way to assess the severity of a skin condition in humans.
research Histologic and Immunohistochemical Evaluation of Lichen Planopilaris and Correlation with Clinical Disease Severity
The study found a link between the severity of Lichen Planopilaris seen by doctors and the details seen under a microscope, and created a new way to measure this severity.
research Fibrinogen and LDL Apheresis in Treatment of Sudden Hearing Loss: A Randomised Multicentre Trial
Fibrinogen/LDL apheresis may improve speech perception in sudden hearing loss, especially for those with high fibrinogen and LDL levels.
research Vestibular Hair Cell Regeneration and Restoration of Balance Function Induced by Math1 Gene Transfer
Gene therapy with the Math1 gene helped regenerate balance-related cells and improve balance in mice.
research Development of Gene Therapy for Inner Ear Disease: Using Bilateral Vestibular Hypofunction as a Vehicle for Translational Research
Gene therapy, especially using atoh1, shows promise for creating functional sensory hair cells in the inner ear, but dosing and side effects need to be managed for clinical application.
research Cutaneous Side-Effects of Beta-Adrenergic Blockers
Beta-blockers can cause rare skin side-effects, which usually improve after stopping the medication.
research Branching of Spiral Ganglion Neurites Induced by Focal Application of Fibroblast Growth Factor-1
FGF-1 causes spiral ganglion neurites to branch more.
research Adenosine A2B Receptor: A Pathogenic Factor and a Therapeutic Target for Sensorineural Hearing Loss
Blocking adenosine A2B receptor may prevent or treat hearing loss.