Histologic and Immunohistochemical Evaluation of Lichen Planopilaris and Correlation with Clinical Disease Severity

    April 2017 in “ Journal of Investigative Dermatology ”
    Martina L. Porter, Mariko Yasuda, Ruth K. Foreman, Mai P. Hoang, Athena Manatis-Lornell, Maryanne M. Senna
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    TLDR The study found a link between the severity of Lichen Planopilaris seen by doctors and the details seen under a microscope, and created a new way to measure this severity.
    The document presents a small pilot study that aimed to correlate clinical severity of Lichen Planopilaris (LPP), a primary cicatricial alopecia, with histologic findings and to develop an immunohistochemical scoring system for grading disease activity. The study included ten patients with biopsy-confirmed LPP. Clinical disease severity at the time of biopsy was graded using a new scoring system developed at Massachusetts General Hospital. Biopsy specimens were evaluated using immunohistochemistry markers CD8, CD123, and CK15, as well as assessing sebaceous glands, presence of mast cells, and location of inflammation. The study found a correlation between the clinical severity scoring system and the histologic severity. The immunohistochemical scoring system developed could potentially be used to assess LPP severity and response to treatment, which may improve the evaluation of treatment options for LPP in clinical trials.
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      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  94 upvotes 4 weeks ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 7 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  55 upvotes 1 week ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 7 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

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