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research Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review
This review discusses mesenchymal stromal cell-conditioned medium for various skin conditions and found improvements in wound healing, hair restoration, and more, but emphasizes the need for further research to validate these findings.
research Heterozygous COL5A1 deletion in a cat with classical Ehlers–Danlos syndrome
The researchers investigated a Maine Coon cat with suspected classical Ehlers-Danlos Syndrome and discovered a heterozygous deletion in the COL5A1 gene, underscoring the value of whole-genome sequencing for precise veterinary diagnostics.
research hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis
In liver cancer cells, this study found that upregulating hsa_circ_0002980 inhibits cell proliferation, metastasis, and EMT by modulating the miR-1303/CADM2 axis, suggesting it as a potential therapeutic target.
research 311 Single-cell transcriptomics reveals distinct molecular programs in folliculotropic mycosis fungoides
This study revealed distinct cellular and transcriptomic differences among various subtypes of cutaneous T-cell lymphoma, particularly highlighting characteristics unique to folliculotropic mycosis fungoides.
research Unraveling a Rare Case: Diarrhea, Alopecia, and Polyposis
Corticosteroids improved symptoms in a man with Cronkhite-Canada Syndrome.
research MSF-VMDNet for multi class segmentation of skin cancer whole slide images using a multi frequency dual encoder network
In this study, the proposed MSF-VMDNet, combining dual encoder networks with a multi-frequency domain mechanism, significantly outperformed existing methods in segmenting skin cancer tissues from histological slide images, achieving high accuracy with an MIoU of 95.37% and a Dice coefficient of 95.11%.
research MEGA PROTAC, MEGA DOCK-based PROTAC mediated ternary complex formation pipeline with sequential filtering and rank aggregation
This study found that MEGA PROTAC improved the prediction of ternary structures with higher maximum DockQ scores compared to the BOTCP method in 16 out of 22 test cases.
research CPC12 Coinheritance of BRCA2 and CYLD germline pathogenic variants associated with targetable metastatic malignant cylindroma
This study reports a unique case of coinheritance of BRCA2 and CYLD pathogenic variants in a man with metastatic malignant cylindroma, suggesting that recognizing such genetic profiles in rare conditions can provide new treatment options, including the potential use of therapies targeting BRCA deficiency.
research MmuPV1-Induced Cutaneous Squamous Cell Carcinoma Arises Preferentially from Lgr5+ Epithelial Progenitor Cells
This study found that cutaneous squamous cell carcinomas in mice infected with murine papillomavirus preferentially arise from Lgr5+ progenitor cells, while squamous cell dysplasia does not.
research A 25-year-old female with a variable presentation of MCTD-A case report
In this case report, a 25-year-old female with Mixed Connective Tissue Disease presented unusual symptoms in a specific geographical region, prompting clinicians to approach diagnosis and management with caution due to potential severe complications such as pulmonary hypertension and renal crisis.
research `Cyclic alopecia' inMsx2mutants: defects in hair cycling and hair shaft differentiation
In this study, Msx2-deficient mice showed progressive hair loss due to shortened anagen phase and prolonged catagen and telogen phases, resulting in cyclic alopecia with structurally abnormal hair shafts.
research The MHS Hair Restoration Protocol: A Systems-Biology Integration of Nutritional Support, Microbiome Modulation, and Targeted Topical ECS Therapeutics
This study introduces the MHS Hair Restoration Protocol, a systems-biology model targeting hair follicle health through the gut-microbiome-endocannabinoidome axis and innovative topical treatments, emphasizing a holistic approach to pattern hair loss.
research A new tool for conditional gene manipulation in a subset of keratin‐expressing epithelia
This study reported that a Megsin-Cre transgene enables genetic manipulation primarily in skin, forestomach, and esophagus tissues, offering a new tool for studying development and diseases in these areas.
research Novel Compound Heterozygous Variants in the CDC6 Gene in a Russian Patient with Meier-Gorlin Syndrome
This case report presents the first Russian patient with Meier-Gorlin syndrome 5, expanding clinical understanding through the identification of two novel CDC6 gene variants.
research Minoxidil and bilateral central serous chorioretinopathy in an adolescent girl: relationship or causality?
This study indicates that central serous chorioretinopathy linked to topical minoxidil use is rare, suggesting the need for early detection and discontinuation if it occurs.
research Development of a portable reflectance confocal microscope and its application in the noninvasive in vivo evaluation of mesenchymal stem cell-promoted cutaneous wound healing
This study demonstrates that the newly developed portable reflectance confocal microscope (PRCM) offers real-time, noninvasive monitoring of wound healing processes by visualizing skin morphology in both mice and humans.
research Chemical Gastroenterocolitis after Dental Root Canal Therapy with Camphorated and Mentholated Chlorophenol
In this case study, a man's hair and nail symptoms, following dental treatments, resolved with mesalazine therapy after investigating suspected clindamycin allergy and diagnosing mucosal changes.
research Un(MaSC)ing Stem Cell Dynamics in Mammary Branching Morphogenesis
This study reported that mammary stem cells in terminal end buds of the mammary gland primarily contribute to branching morphogenesis through dynamic positional regulation and cellular rearrangement.
research Primary cicatricial alopecia associated with systemic indolent mastocytosis
Systemic mastocytosis may cause a type of hair loss called cicatricial alopecia.
research [Two cases of the rare Cronkhite-Canada syndrome].
This study describes two Danish cases of Cronkhite-Canada syndrome presenting with malnutrition and gastrointestinal issues; both patients underwent successful treatment and remission after developing colonic adenocarcinomas.
research OsCSLD1 Mediates NH4+-Dependent Root Hair Growth Suppression and AMT1;2 Expression in Rice (Oryza sativa L.)
This study suggests that CSLD1 is key to nitrogen-dependent root hair elongation and regulation of AMT1;2 expression in rice roots.
research The MHS Hair Restoration Protocol: A Systems-Biology Integration of Nutritional Support, Microbiome Modulation, and Targeted Topical ECS Therapeutics
This research introduces the MHS Hair Restoration Protocol, which is a comprehensive approach aimed at restoring the hair follicle environment by modulating the gut-microbiome-endocannabinoidome axis and incorporating specific dietary and topical strategies, rather than focusing only on short-term hair count improvements.
research Follicular induction and CK20+ Merkel cells overlying cutaneous focal mucinosis
This study found that 11% of cutaneous focal mucinosis lesions demonstrated follicular induction, which can mimic basal cell carcinoma histologically and complicate diagnosis.
research SUN-305 Hair Cortisol Measurement: An Innovative Method for Diagnosis and Follow-Up in Patients with Cushing’s Disease
This study suggests that hair cortisol measurement could serve as an alternative diagnostic method for Cushing’s disease, showing acceptable concordance with urinary free cortisol despite differing evaluated periods.
research Therapeutic Application of Microsponges-based Drug Delivery Systems
This review discusses the benefits and applications of microsponges delivery systems in drug delivery, particularly for topical treatments, and reports no new clinical findings.
research The comparison of the mesenchymal progenitor cell coating state on the MBA and DBM as the biochemical scaffolds
The demineralized bone matrix scaffold is better for cell attachment than the mineralized bone allograft.
research Patched-assoziierte Tumoren: Modifikatorgene und Pathogenese
This study identified a genetic locus associated with rhabdomyosarcoma susceptibility in mice and found that specific differentiation markers are linked to the regression of basal cell carcinoma.
research Successful Treatment of Cutaneous Mast Cell Tumors in Cats Using Electrochemotherapy: A Case Series
This case series reports that electrochemotherapy with intravenous bleomycin effectively resolved cutaneous mast cell tumors in four cats, showing no tumor recurrence during follow-up, except for new lesions in one cat, and minimal local toxicity.
research Multi-Walled Carbon Nanotubes Can Promote Brassica napus L. and Arabidopsis thaliana L. Root Hair Development through Nitric Oxide and Ethylene Pathways
This study found that multi-walled carbon nanotubes promoted root hair growth in certain plants, with results indicating they modulate nitric oxide and ethylene pathways crucial to this development.