Sun-305 Hair Cortisol Measurement: An Innovative Method for Diagnosis and Follow-Up in Patients with Cushing's Disease

April 2020 in “ Journal of the Endocrine Society ”

Natalia Gabriela Deligiannis, Soledad Sosa, Diego González, Carolina Ibar, Darío Jacobsen, Bibiana Fabre, Karina Danilowicz

hair cortisol measurement Cushing’s disease hypercortisolism urinary free cortisol

TLDR Hair cortisol measurement can help diagnose and monitor Cushing’s disease.

The study evaluated hair cortisol measurement (HCM) as a diagnostic tool for Cushing’s disease (CD), involving 23 CD patients and 50 controls. HCM was proposed as an additional test for hypercortisolism, showing acceptable concordance with urinary free cortisol (UFC) despite different evaluation periods. Results indicated significant differences in HCM values between controlled or active CD patients and controls, suggesting HCM as a viable alternative for diagnosing and monitoring CD. The study highlighted the potential of HCM to reflect cortisol exposure over three months, offering a non-invasive method for assessing CD status.

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Sun-305 Hair Cortisol Measurement: An Innovative Method for Diagnosis and Follow-Up in Patients with Cushing's Disease

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