23 citations
,
January 2023 in “Journal of Developmental Biology” In this study, researchers discussed how specific protein interactions in reptile skin allow for the development of protective structures like scales and scutes, which facilitated reptiles' adaptation to terrestrial environments.
21 citations
,
November 1980 in “PubMed” This study describes a newly identified mite species, Demodex zalophi, found on captive sea lions and highlights its unique traits, including being the first of its kind described in marine mammals.
18 citations
,
January 2018 in “Advances in experimental medicine and biology” This review discusses the evolutionary history of keratins and reports no new results, highlighting key events that contributed to the development of mammalian hair and integument.
14 citations
,
May 2016 in “International Journal of Molecular Sciences” This study showed that knocking out the Ppp2ca gene in the epidermis of mice led to significant hair loss and disrupted hair follicle morphogenesis and regeneration.
7 citations
,
March 1986 in “British Veterinary Journal” Canine skin has two main layers: the epidermis and dermis, with a supportive subcutis layer.
3 citations
,
December 2018 in “Routledge eBooks” This chapter reviews the chemistry of keratin fibers, which are essential for understanding the structural stability and functionality of mammalian hair and other similar biological materials.
January 2005 in “Chinese Journal of Veterinary” This study observed that hairless mice of different strains initially grow hair but soon develop alopecia and other skin and pigmentation changes with age.
January 2004 in “Laboratory Animal Science and Administration” This study found that the hairless mutant gene in C 57BL/6 mice affects the hair follicle cycle and leads to early thymus degeneration and distinct skin changes.
178 citations
,
October 2001 in “Genes & Development” This study found that the mammalian hairless gene encodes a corepressor protein that interacts with thyroid hormone receptors, providing insights into hair loss syndromes in humans and mice.
129 citations
,
January 2004 in “Journal of medicinal chemistry” This study synthesized nonsteroidal ligands as second-generation androgen receptor agonists and identified three compounds with significant anabolic activity and moderate to minimal androgenic activity in vivo.
91 citations
,
April 2006 in “PubMed” This review summarizes adverse events associated with EGFR-targeting cancer therapies, such as skin rashes and lung disease, and reports no new clinical results.
68 citations
,
May 2024 in “International Journal of Molecular Sciences” This review of acne management strategies highlights current treatments, such as topical and systemic therapies, procedural methods, and dietary changes, while also discussing emerging options like biologics and probiotics as potential future treatments, emphasizing personalized care due to acne's complex nature.
44 citations
,
October 2020 in “Arthritis Care & Research” This review summarizes various indices used to assess disease activity and damage in systemic lupus erythematosus, highlighting challenges in universal consensus and their practical applications in research and clinical settings.
32 citations
,
April 2011 in “Journal of the American Academy of Dermatology” Erlotinib may cause scarring hair loss.
26 citations
,
September 2002 in “Dermatologic Surgery” This study reports that the prevalence of male pattern baldness in Asians is higher than previously believed, with potential links to socioeconomic factors and westernized diets, though the exact cause remains unclear.
25 citations
,
September 2024 in “Cardiovascular Drugs and Therapy” This study found that while glucagon-like peptide 1 receptor agonists report more incidents of suicide, hair loss, and aspiration compared to some other antidiabetic drugs, they did not meet the threshold for positive safety signals.
19 citations
,
September 2015 in “Therapeutic Delivery” This review discusses the application of active transdermal technologies in cosmetic devices for skin restoration and enhancement, reporting no new clinical results.
17 citations
,
July 2017 in “International Journal of Behavioral Medicine” This study validated the Egyptian Arabic version of the Skindex-16 and found that skin conditions significantly impacted patients' quality of life, particularly in the emotional domain.
17 citations
,
May 1998 in “Steroids” This study constructed a model to predict finasteride's inhibitory activity on 5α-reductase type 2 and calculated that a 1 μM plasma concentration, after 50 mg administration, matches prostate inhibition levels.
16 citations
,
November 2018 in “Medicinal Chemistry” The authors concluded that newly synthesized N-acyl-L-tryptophanyl-isoleucine amides showed high anxiolytic activity in animal models, comparable to diazepam, through interaction with the TSPO receptor.
16 citations
,
December 2016 in “Skin appendage disorders” This study analyzed patch test results to identify allergens causing scalp contact dermatitis, finding nickel, cobalt, and balsam of Peru among the most common in the patient population.
14 citations
,
November 2024 in “Pharmaceuticals” This study found that using spanlastics, a nano, surfactant-based drug delivery system, improved the bioavailability, drug release characteristics, and pharmacokinetic behavior of famotidine, a poorly soluble drug, by enhancing its dissolution and membrane permeation.
13 citations
,
August 2002 in “Dermatologic Surgery” This paper introduces Follicular Unit Extraction and reports the FOX Test can identify suitable candidates, with about 25% of patients being ideal and 35% being good candidates for the procedure.
11 citations
,
March 2025 in “Environmental Monitoring and Assessment” This review discusses how faecal pollution contributes to antimicrobial resistance in surface water and highlights the need for standardized methods and better wastewater management but reports no new clinical results.
11 citations
,
April 2021 in “Cancers” This study identified a small molecule that activates GLI1, suppressing neuroblastoma cell growth, which may aid in developing new treatments for high-risk neuroblastoma cases.
11 citations
,
June 2016 in “npj Regenerative Medicine” This symposium discussed why regenerative capacity varies among species and diminishes with age, exploring how these insights could inform regenerative medicine approaches, without presenting new experimental results.
8 citations
,
January 2022 in “Sensors” This study analyzed deep learning's application to automate hair density measurement in images and found that YOLOv4 had the best performance among tested algorithms, with a mean average precision of 58.67.
8 citations
,
June 2016 in “Journal of Pharmacy Practice” This case report suggests that lisinopril may cause alopecia, which resolved after the patient switched to losartan potassium.
7 citations
,
August 2023 in “Dermatologic Surgery” In this study, researchers reported that a new skin-responsive FU excision device consistently succeeded in all patients of African descent, showing a mean graft transection rate of less than 10%, with skin thickness and firmness identified as major factors affecting graft attrition rate.
7 citations
,
June 2020 in “Translational Andrology and Urology” This study evaluated potential penile vascular changes and persistent adverse effects in men discontinuing 5α-reductase inhibitors for androgenic alopecia, but no new clinical results were reported.